Activase and Zenpep drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Activase (alteplase) and Zenpep (pancrelipase (amylase;lipase;protease)). Common drug interactions include dyspnoea among females and infective pulmonary exacerbation of cystic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Activase and Zenpep. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Activase?

Activase has active ingredients of alteplase. eHealthMe is studying from 7,526 Activase users. Check the latest studies of Activase.

What is Zenpep?

Zenpep has active ingredients of pancrelipase (amylase;lipase;protease). eHealthMe is studying from 5,529 Zenpep users. Check the latest studies of Zenpep.

On Jul, 14, 2026

11 people who take Activase and Zenpep together, and have interactions are studied.

What are the common drug interactions of Activase and Zenpep, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Bacterial infection
Blood albumin decreased
Blood calcium decreased
Cough
Decreased activity
Decreased appetite
Dyspepsia (indigestion)
Glycosylated haemoglobin increased

male:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Nausea (feeling of having an urge to vomit)
Influenza
Productive cough
Pulmonary congestion (congestion in the lungs)
Rhinorrhoea (watery mucus discharge from the nose)
Sputum increased
Vitamin d deficiency
White blood cell count increased
Cystic fibrosis (disease of the secretary glands)

What are the common drug interactions of Activase and Zenpep, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Blood alkaline phosphatase increased
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Forced expiratory volume decreased (decreased lung expired air volume)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Haemoglobin decreased
Heart rate increased
Influenza
Nausea (feeling of having an urge to vomit)

30-39:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Pain
Pulmonary congestion (congestion in the lungs)
Wheezing (a high-pitched whistling sound made while you breath)

40-49:

Bacterial infection
Blood albumin decreased
Blood calcium decreased
Cough
Decreased activity
Decreased appetite
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Glycosylated haemoglobin increased

50-59:

Cardiorenal syndrome (kidney failure and heart failure)
Cellulitis (infection under the skin)
Chronic kidney disease
Hypervolaemia (abnormally increased volume of blood)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotension (abnormally low blood pressure)
Impaired gastric emptying
Implant site infection
Lethargy (tiredness)
Nausea (feeling of having an urge to vomit)

60+:

Cystic fibrosis (disease of the secretary glands)
Depression
Haematemesis (vomiting of blood)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Infective exacerbation of bronchiectasis (severe infective lung disease)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 10 people, 90.91%
Indigestion: 8 people, 72.73%
Constipation: 8 people, 72.73%
Pain: 8 people, 72.73%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 54.55%
Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 6 people, 54.55%
Headache (pain in head): 5 people, 45.45%
Infective Pulmonary Exacerbation Of Cystic Fibrosis (severe infective lung disease with production of abnormally thick mucus): 4 people, 36.36%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 4 people, 36.36%
Hypokalemia (low potassium): 4 people, 36.36%

* Approximation only. Some reports may have incomplete information.

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