Activase and Zometa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Activase (alteplase) and Zometa (zoledronic acid). Common drug interactions include anxiety among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Activase and Zometa. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Activase?

Activase has active ingredients of alteplase. eHealthMe is studying from 7,526 Activase users. Check the latest studies of Activase.

What is Zometa?

Zometa has active ingredients of zoledronic acid. It is often used in multiple myeloma. eHealthMe is studying from 71,434 Zometa users. Check the latest studies of Zometa.

On Jul, 28, 2026

90 people who take Activase and Zometa together, and have interactions are studied.

What are the common drug interactions of Activase and Zometa, by gender? *:

female:

Anxiety
Osteonecrosis of jaw (death of bone of jaw)
Oedema peripheral (superficial swelling)
Nausea (feeling of having an urge to vomit)
Diarrhoea
Injury
Fall
Pain in extremity
Sinusitis (inflammation of sinus)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

male:

Pain
Fatigue (feeling of tiredness)
Asthenia (weakness)
Gait disturbance
Hypophagia (reduced food intake)
Injury
Intervertebral disc degeneration (spinal disc degeneration)
Pneumonia
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Insomnia (sleeplessness)

What are the common drug interactions of Activase and Zometa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Pain
Pneumonia
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Anxiety
Dyspnoea (difficult or laboured respiration)
Insomnia (sleeplessness)
Osteonecrosis of jaw (death of bone of jaw)
Pathological fracture (broken bone caused by disease)
Skin lesion

50-59:

Injury
Osteonecrosis of jaw (death of bone of jaw)
Cough
Cardiomegaly (increased size of heart than normal)
Gait disturbance
Pleural fibrosis (formation of fibrous tissue in lung)
Intervertebral disc degeneration (spinal disc degeneration)
Diarrhoea
Atelectasis (partial or complete collapse of the lung)
Faecal incontinence (a lack of control over passing stool)

60+:

Pain
Anxiety
Vomiting
Balance disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Osteomyelitis (infection of bone)
Swelling face
Fall
Injury
Interstitial lung disease

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 19 people, 21.11%
Bone Density Abnormal: 14 people, 15.56%
Pain: 13 people, 14.44%
Stress And Anxiety: 9 people, 10.00%
Breast Cancer Female: 8 people, 8.89%
Constipation: 7 people, 7.78%
Osteoporosis (bones weak and more likely to break): 6 people, 6.67%
Insomnia (sleeplessness): 5 people, 5.56%
High Blood Pressure: 5 people, 5.56%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 5 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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