Activella and Sumatriptan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Activella (estradiol; norethindrone acetate) and Sumatriptan (sumatriptan succinate). Common drug interactions include abdominal discomfort among females.

The phase IV clinical study analyzes what interactions people have when they take Activella and Sumatriptan. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Activella?

Activella has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 1,971 Activella users. Check the latest studies of Activella.

What is Sumatriptan?

Sumatriptan has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 18,159 Sumatriptan users. Check the latest studies of Sumatriptan.

On Jul, 18, 2026

11 people who take Activella and Sumatriptan together, and have interactions are studied.

Activella and Sumatriptan drug interactions.

What are the common drug interactions of Activella and Sumatriptan, by gender? *:

female:

Abdominal discomfort
Bone density decreased
Suicidal ideation
Urinary tract infection
Vertigo
Fatigue (feeling of tiredness)
Injection site pain
Abortion spontaneous (naturally occurring miscarriage)
Maternal exposure during pregnancy (use of substance during pregnancy)
Headache (pain in head)

male:

n/a

What are the common drug interactions of Activella and Sumatriptan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Suicidal ideation

30-39:

Maternal exposure during pregnancy (use of substance during pregnancy)
Abortion spontaneous (naturally occurring miscarriage)

40-49:

Bone density decreased

50-59:

Injection site pain
Fatigue (feeling of tiredness)
Joint swelling
Oedema peripheral (superficial swelling)

60+:

Abdominal discomfort
Fatigue (feeling of tiredness)
Headache (pain in head)
Ocular hypertension (intraocular pressure higher than normal)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 27.27%
Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 2 people, 18.18%
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 2 people, 18.18%
Muscle Spasms (muscle contraction): 2 people, 18.18%
Seasonal Allergy (allergic condition due to certain season): 2 people, 18.18%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 1 person, 9.09%
Depression: 1 person, 9.09%
Dysmenorrhea (painful menstruation): 1 person, 9.09%
Gastric Ulcer (stomach ulcer): 1 person, 9.09%
Headache (pain in head): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Activella and Sumatriptan?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously