Actonel and Isosorbide dinitrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actonel (risedronate sodium) and Isosorbide dinitrate (isosorbide dinitrate). Common drug interactions include diarrhoea among females and myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Actonel and Isosorbide dinitrate. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

On Jul, 23, 2026

56 people who take Actonel and Isosorbide dinitrate together, and have interactions are studied.

Actonel and Isosorbide dinitrate drug interactions.

What are the common drug interactions of Actonel and Isosorbide Dinitrate, by gender? *:

female:

Diarrhoea
Gait disturbance
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Chest pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Fatigue (feeling of tiredness)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Neuralgia (pain in one or more nerves)
Pneumonia

male:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure (kidney dysfunction)
Hypoaesthesia (reduced sense of touch or sensation)
Peritoneal hernia
Pneumonia
Renal artery stenosis (narrowing of renal artery)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fall
Urinary tract infection
Back pain

What are the common drug interactions of Actonel and Isosorbide Dinitrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anal abscess

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

50-59:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Rectal haemorrhage (bleeding from anus)
Renal failure chronic (long lasting kidney dysfunction)
Vomiting
Cardiac enzymes increased

60+:

Cardiac failure congestive
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Neuralgia (pain in one or more nerves)
Pneumonia
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Arthralgia (joint pain)
Cardiac failure
Cellulitis (infection under the skin)
Dehydration (dryness resulting from the removal of water)
Femoral neck fracture (neck of femur bone fracture)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 12.50%
High Blood Pressure: 7 people, 12.50%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 10.71%
Neuralgia (pain in one or more nerves): 4 people, 7.14%
Diabetes: 4 people, 7.14%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 7.14%
Stable Angina (a constant chest pain): 3 people, 5.36%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 5.36%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

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