Actonel and Naltrexone hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actonel (risedronate sodium) and Naltrexone hydrochloride (naltrexone hydrochloride). Common drug interactions include arthralgia among females and tracheal obstruction among males.

The phase IV clinical study analyzes what interactions people have when they take Actonel and Naltrexone hydrochloride. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Naltrexone hydrochloride?

Naltrexone hydrochloride has active ingredients of naltrexone hydrochloride. It is often used in alcoholism. eHealthMe is studying from 1,712 Naltrexone hydrochloride users. Check the latest studies of Naltrexone hydrochloride.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

12 people who take Actonel and Naltrexone hydrochloride together, and have interactions are studied.

Actonel and Naltrexone hydrochloride drug interactions.

What are the common drug interactions of Actonel and Naltrexone Hydrochloride, by gender? *:

female:

Arthralgia (joint pain)
Bone disorder
Femur fracture
Fracture displacement
Fracture nonunion (permanent failure of healing following a broken bone)
Groin pain
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
Mobility decreased (ability to move is reduced)
Osteoporotic fracture (fracture due to weak bone)
Pain

male:

Tracheal obstruction (blockage of trachea)
Arthralgia (joint pain)
Haematoma (collection of blood outside the blood vessels)
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
Mass
Mobility decreased (ability to move is reduced)
Monoparesis (one limb is very weak, but not completely paralyzed)
Muscle injury
Osteoporotic fracture (fracture due to weak bone)
Pain

What are the common drug interactions of Actonel and Naltrexone Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthralgia (joint pain)
Bone disorder
Dysstasia (difficulty in standing)
Femur fracture
Fracture delayed union (delayed cure of broken bone)
Fracture displacement
Fracture nonunion (permanent failure of healing following a broken bone)
Groin pain
Haematoma (collection of blood outside the blood vessels)
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)

40-49:

Tracheal obstruction (blockage of trachea)

50-59:

Arthralgia (joint pain)
Bone disorder
Pathological fracture (broken bone caused by disease)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Fall
Mass
Staphylococcal infection (an infection with staphylococcus bacteria)
Hip deformity
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Muscle haemorrhage (bleeding in muscle)

60+:

n/a

What are the existing conditions these people have? *

Depression: 3 people, 25.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 16.67%
Stress And Anxiety: 1 person, 8.33%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 8.33%
Irritable Bowel Syndrome: 1 person, 8.33%
Insomnia (sleeplessness): 1 person, 8.33%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 8.33%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 8.33%
Facial Nerve Disorder (disease of face nerve): 1 person, 8.33%
Bone Disorder: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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