Actonel and Pulmicort flexhaler drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actonel (risedronate sodium) and Pulmicort flexhaler (budesonide). Common drug interactions include bone density decreased among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Actonel and Pulmicort flexhaler. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Pulmicort flexhaler?

Pulmicort flexhaler has active ingredients of budesonide. It is often used in asthma. eHealthMe is studying from 5,527 Pulmicort flexhaler users. Check the latest studies of Pulmicort flexhaler.



On Jul, 10, 2026

12 people who take Actonel and Pulmicort flexhaler together, and have interactions are studied.

Actonel and Pulmicort flexhaler drug interactions.

What are the common drug interactions of Actonel and Pulmicort Flexhaler, by gender? *:

female:

  1. Bone density decreased
  2. Wheezing (a high-pitched whistling sound made while you breath)
  3. Dyspnoea (difficult or laboured respiration)
  4. Drug effect decreased
  5. Exostosis (formation of new bone on the surface of a bone)
  6. Skin cancer
  7. Uterine prolapse
  8. Cough
  9. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  10. Weight decreased

male:

  1. Asthenia (weakness)
  2. Clostridial infection (infectious conditions by clostridium bacteria)
  3. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  4. Diarrhoea
  5. Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
  6. Fatigue (feeling of tiredness)
  7. Hypotension (abnormally low blood pressure)
  8. Malaise (a feeling of general discomfort or uneasiness)
  9. Pneumonia
  10. Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)

What are the common drug interactions of Actonel and Pulmicort Flexhaler, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Asthenia (weakness)
  2. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  3. Diarrhoea
  4. Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
  5. Fatigue (feeling of tiredness)
  6. Hypotension (abnormally low blood pressure)
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)

60+:

  1. Bone density decreased
  2. Wheezing (a high-pitched whistling sound made while you breath)
  3. Body height decreased
  4. Chest discomfort
  5. Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
  6. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  7. Diastolic dysfunction
  8. Disease recurrence
  9. Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
  10. Dysphonia (speech disorder attributable to a disorder of phonation)

What are the existing conditions these people have? *

  1. Cough: 2 people, 16.67%
  2. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 16.67%
  3. Sinus Disorder (disease of sinus): 1 person, 8.33%
  4. Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 1 person, 8.33%
  5. Pain: 1 person, 8.33%
  6. Macular Degeneration (painless eye condition that leads to the gradual loss of central vision): 1 person, 8.33%
  7. Immunodeficiency Common Variable: 1 person, 8.33%
  8. High Blood Pressure: 1 person, 8.33%
  9. High Blood Cholesterol: 1 person, 8.33%
  10. Depression: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and Pulmicort flexhaler?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Actonel and Pulmicort flexhaler:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Pulmicort flexhaler:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Actonel and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Pulmicort flexhaler and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium and budesonide (the active ingredients of Actonel and Pulmicort flexhaler, respectively), and Actonel and Pulmicort flexhaler (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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