Actonel and Versed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actonel (risedronate sodium) and Versed (midazolam hydrochloride). Common drug interactions include injury among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Actonel and Versed. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Versed?

Versed has active ingredients of midazolam hydrochloride. It is often used in sedation during medical procedure. eHealthMe is studying from 6,869 Versed users. Check the latest studies of Versed.

On Jul, 30, 2026

34 people who take Actonel and Versed together, and have interactions are studied.

What are the common drug interactions of Actonel and Versed, by gender? *:

female:

Injury
Dizziness
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Bone disorder
Disability
Erythema (redness of the skin)
Oral disorder (mouth disease)
Swelling
Abdominal pain
Depression

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Intervertebral disc degeneration (spinal disc degeneration)
Metastases to bone (cancer spreads to bone)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis of jaw (death of bone of jaw)
Pain
Rectal haemorrhage (bleeding from anus)
Renal failure (kidney dysfunction)

What are the common drug interactions of Actonel and Versed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)

50-59:

Weight increased
Wrist fracture
Appetite disorder (abnormal eating habits)
Chills (felling of cold)
Dyspepsia (indigestion)
Incontinence (lack of moderation or self-control)
Osteoradionecrosis (irradiation of bones causes damage to osteocytes and impairs the blood supply)
Pyrexia (fever)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Urticaria (rash of round, red welts on the skin that itch intensely)

60+:

Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Dysgeusia (disorder of the sense of taste)
Emotional distress
Fatigue (feeling of tiredness)
Fear
Injury
Nausea (feeling of having an urge to vomit)
Pain
Pancreatic cyst

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 15 people, 44.12%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 15 people, 44.12%
Pain: 9 people, 26.47%
Prostate Cancer: 4 people, 11.76%
High Blood Cholesterol: 4 people, 11.76%
High Blood Pressure: 3 people, 8.82%
Thyroid Diseases: 2 people, 5.88%
Multiple Allergies (allergy to multiple agents): 2 people, 5.88%
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium): 2 people, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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