Actonel and Zelnorm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actonel (risedronate sodium) and Zelnorm (tegaserod maleate). Common drug interactions include fall among females.

The phase IV clinical study analyzes what interactions people have when they take Actonel and Zelnorm. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Zelnorm?

Zelnorm has active ingredients of tegaserod maleate. eHealthMe is studying from 7,261 Zelnorm users. Check the latest studies of Zelnorm.

On Aug, 01, 2026

82 people who take Actonel and Zelnorm together, and have interactions are studied.

What are the common drug interactions of Actonel and Zelnorm, by gender? *:

female:

Fall
Abdominal pain
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Muscular weakness (muscle weakness)
Oedema peripheral (superficial swelling)
Abdominal pain upper
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Retching (strong involuntary effort to vomit)
Tooth fracture
Anaemia (lack of blood)

male:

n/a

What are the common drug interactions of Actonel and Zelnorm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain upper
Anxiety
Fall
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Memory impairment
Oropharyngeal pain
Abdominal pain
Actinomycosis (infection that causes sores, or abscesses)

50-59:

Constipation
Impaired healing
Oedema peripheral (superficial swelling)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Anaemia (lack of blood)
Deformity (disfigurement)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Muscular weakness (muscle weakness)
Pyrexia (fever)
Abdominal pain upper

60+:

Fall
Femur fracture
Spinal compression fracture (fracture due to spinal compression on bone)
Pain in extremity
Bone callus excessive (excessive bony deposit formed between and around the broken ends of bone fractures)
Bone disorder
Diarrhoea
Flatulence (flatus expelled through the anus)
Foot fracture
Fracture nonunion (permanent failure of healing following a broken bone)

What are the existing conditions these people have? *

Irritable Bowel Syndrome: 23 people, 28.05%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 17 people, 20.73%
Multiple Myeloma (cancer of the plasma cells): 14 people, 17.07%
High Blood Pressure: 14 people, 17.07%
Fatigue (feeling of tiredness): 14 people, 17.07%
Constipation: 9 people, 10.98%
Asthma: 5 people, 6.10%

* Approximation only. Some reports may have incomplete information.

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