Actos and Augmentin '125' drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actos (pioglitazone hydrochloride) and Augmentin '125' (amoxicillin; clavulanate potassium). Common drug interactions include osteoarthritis among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Actos and Augmentin '125'. It is created by eHealthMe based on reports of 95 people who take the same drugs from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Augmentin '125'?

Augmentin '125' has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 10,452 Augmentin '125' users. Check the latest studies of Augmentin '125'.

On Jul, 20, 2026

95 people who take Actos and Augmentin '125' together, and have interactions are studied.

Actos and Augmentin '125' drug interactions.

What are the common drug interactions of Actos and Augmentin '125', by gender? *:

female:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis of jaw (death of bone of jaw)
Diarrhoea
Osteoporosis (bones weak and more likely to break)
Anaemia (lack of blood)
Bone disorder
Osteolysis (dissolution of bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Spinal osteoarthritis (joint cartilage loss in spine)
Exostosis (formation of new bone on the surface of a bone)

male:

Back pain
Anxiety
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Injury
Pyrexia (fever)
Dysphagia (a condition in which swallowing is difficult or painful)
Sepsis (a severe blood infection that can lead to organ failure and death)
Tooth abscess (pus formation in tooth)
Abdominal discomfort
Bone disorder

What are the common drug interactions of Actos and Augmentin '125', by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Premature baby

10-19:

n/a

20-29:

n/a

30-39:

Back pain
Blood cholesterol increased
Blood triglycerides increased
Cellulitis (infection under the skin)
Erectile dysfunction
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Joint sprain (an injury to joint surrounding flexible fibres)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oedema peripheral (superficial swelling)

40-49:

Rash
Anxiety
Cardiac murmur (an heart sound in valve abnormality)
Cellulitis (infection under the skin)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Depression
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diabetic ulcer
Fungal infection

50-59:

Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Osteonecrosis of jaw (death of bone of jaw)
Stomatitis (inflammation of mucous membrane of mouth)
Oedema peripheral (superficial swelling)
Osteoporosis (bones weak and more likely to break)
Sepsis (a severe blood infection that can lead to organ failure and death)
Swelling
Cellulitis (infection under the skin)
Diarrhoea
Escherichia infection (bacterial infection by escherichia coli)

60+:

Anxiety
Back pain
Abdominal pain
Bone disorder
Osteonecrosis of jaw (death of bone of jaw)
Tooth loss
Cardiomegaly (increased size of heart than normal)
Asthenia (weakness)
Renal failure (kidney dysfunction)
Weight decreased

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 22 people, 23.16%
Multiple Myeloma (cancer of the plasma cells): 22 people, 23.16%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 21 people, 22.11%
Thrombocytopenia (decrease of platelets in blood): 11 people, 11.58%

* Approximation only. Some reports may have incomplete information.

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