Actos and Bactrim ds drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actos (pioglitazone hydrochloride) and Bactrim ds (sulfamethoxazole; trimethoprim). Common drug interactions include dyspnoea among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Actos and Bactrim ds. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Bactrim ds?

Bactrim ds has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 17,027 Bactrim ds users. Check the latest studies of Bactrim ds.

On Aug, 05, 2026

77 people who take Actos and Bactrim ds together, and have interactions are studied.

What are the common drug interactions of Actos and Bactrim Ds, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Renal failure (kidney dysfunction)
Anxiety
Chronic kidney disease
Coagulopathy (blood's ability to clot is impaired)
Constipation
Dizziness
Headache (pain in head)
Hypophagia (reduced food intake)

male:

Dehydration (dryness resulting from the removal of water)
Diarrhoea
Blood glucose increased
Dysuria (painful or difficult urination)
Erythema (redness of the skin)
Fall
Gingival infection (gum infection)
Hypotension (abnormally low blood pressure)
Anaemia (lack of blood)
Back pain

What are the common drug interactions of Actos and Bactrim Ds, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Pain
Pulmonary embolism (blockage of the main artery of the lung)

40-49:

Chronic kidney disease
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Renal failure (kidney dysfunction)
Abscess limb (limb infection)
Depression
Erythema (redness of the skin)
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
General physical health deterioration (weak health status)
Groin abscess (pus in groin)
Joint contracture (a permanent shortening of a muscle or joint)

50-59:

Pain
Abnormal behaviour
Anxiety
Blood creatinine increased
Bone disorder
Cellulitis (infection under the skin)
Cerebral haemorrhage (bleeding within the brain)
Chest pain
Death
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)

60+:

Dehydration (dryness resulting from the removal of water)
Diarrhoea
Coagulopathy (blood's ability to clot is impaired)
Dizziness
Febrile neutropenia (fever with reduced white blood cells)
Headache (pain in head)
Insomnia (sleeplessness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nausea (feeling of having an urge to vomit)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)

What are the existing conditions these people have? *

Type 2 Diabetes: 15 people, 19.48%
High Blood Pressure: 15 people, 19.48%
Hiv Infection: 9 people, 11.69%
Pain: 8 people, 10.39%
Nausea (feeling of having an urge to vomit): 8 people, 10.39%
Depression: 7 people, 9.09%
Stress And Anxiety: 6 people, 7.79%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 7.79%
Nausea And Vomiting: 5 people, 6.49%
Muscle Spasms (muscle contraction): 5 people, 6.49%

* Approximation only. Some reports may have incomplete information.

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