Actos and Epzicom drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actos (pioglitazone hydrochloride) and Epzicom (abacavir sulfate; lamivudine). Common drug interactions include sepsis among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Actos and Epzicom. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Epzicom?

Epzicom has active ingredients of abacavir sulfate; lamivudine. It is often used in hiv infection. eHealthMe is studying from 4,937 Epzicom users. Check the latest studies of Epzicom.

On Jul, 20, 2026

22 people who take Actos and Epzicom together, and have interactions are studied.

What are the common drug interactions of Actos and Epzicom, by gender? *:

female:

Sepsis (a severe blood infection that can lead to organ failure and death)
Skin lesion
Stomatitis (inflammation of mucous membrane of mouth)
Stress
Upper respiratory tract infection
Vomiting
Weight decreased
Back pain
Decreased appetite
Renal impairment (severely reduced kidney function)

male:

Chronic kidney disease
Emotional distress
Aspartate aminotransferase increased
Asthenia (weakness)
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
Depression
Diarrhoea
Drug ineffective
Fatigue (feeling of tiredness)
Mobility decreased (ability to move is reduced)

What are the common drug interactions of Actos and Epzicom, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Haemoglobin decreased
Headache (pain in head)
Hypersensitivity
Lethargy (tiredness)
Myalgia (muscle pain)
Pain
Pyrexia (fever)
Red blood cell sedimentation rate increased
White blood cell count decreased
Alanine aminotransferase increased

50-59:

Pyrexia (fever)
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
Chronic kidney disease
Emotional distress
Pain
Renal impairment (severely reduced kidney function)
Abdominal pain
Alanine aminotransferase increased
Anal haemorrhage
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Abdominal distension
Abdominal pain
Asthenia (weakness)
Blood glucose increased
Blood pressure increased
Chills (felling of cold)
Decreased appetite
Drug effect decreased

What are the existing conditions these people have? *

Pain: 5 people, 22.73%
High Blood Pressure: 5 people, 22.73%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 18.18%
Depression: 4 people, 18.18%
Nausea And Vomiting: 4 people, 18.18%
Type 2 Diabetes: 4 people, 18.18%
Blood Testosterone Decreased: 3 people, 13.64%
Gout (uric acid crystals building up in the body): 3 people, 13.64%
Prostatomegaly (enlargement of the prostate): 3 people, 13.64%
Chest Pain: 3 people, 13.64%

* Approximation only. Some reports may have incomplete information.

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