Actos and Hydrocodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actos (pioglitazone hydrochloride) and Hydrocodone (hydrocodone bitartrate; ibuprofen). Common drug interactions include oedema among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Actos and Hydrocodone. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

On Jul, 15, 2026

72 people who take Actos and Hydrocodone together, and have interactions are studied.

Actos and Hydrocodone drug interactions.

What are the common drug interactions of Actos and Hydrocodone, by gender? *:

female:

Oedema (fluid collection in tissue)
Sinusitis (inflammation of sinus)
Tenderness (pain or discomfort when an affected area is touched)
Hypotension (abnormally low blood pressure)
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Fatigue (feeling of tiredness)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Abdominal pain upper
Anxiety

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Application site reaction
Disease recurrence
Ear discomfort
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Feeling jittery
Headache (pain in head)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)

What are the common drug interactions of Actos and Hydrocodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Renal failure (kidney dysfunction)
Anxiety
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Fibromyalgia (a long-term condition which causes pain all over the body)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Mania (a state of abnormally elevated or irritable mood)
Nephrogenic anaemia (anaemia due to kidney disease)
Neuropathy peripheral (surface nerve damage)
Renal tubular necrosis (death of kidney tubules)

40-49:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Constipation
Emotional distress
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Lower limb fracture
Pain
Pain in extremity
Abdominal pain

50-59:

Fall
Fatigue (feeling of tiredness)
Gingival disorder (gum disease)
Hair colour changes
Hair disorder
Impaired healing
Influenza like illness
Insomnia (sleeplessness)
Lower limb fracture
Muscular weakness (muscle weakness)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Blood potassium decreased
Diarrhoea
Dizziness
Hypotension (abnormally low blood pressure)
Injection site erythema (redness at injection site)
Injection site irritation
Injection site pruritus (severe itching at injection site)
Injection site swelling

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 28 people, 38.89%
High Blood Cholesterol: 24 people, 33.33%
Pain: 22 people, 30.56%
Depression: 19 people, 26.39%
Stress And Anxiety: 17 people, 23.61%
High Blood Pressure: 16 people, 22.22%
Constipation: 14 people, 19.44%
Insomnia (sleeplessness): 11 people, 15.28%
Dyspnea (difficult or laboured breathing): 10 people, 13.89%
Type 2 Diabetes: 9 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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