Actos and Ms contin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actos (pioglitazone hydrochloride) and Ms contin (morphine sulfate). Common drug interactions include hydrocephalus among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Actos and Ms contin. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Ms contin?

Ms contin has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 69,289 Ms contin users. Check the latest studies of Ms contin.

On Jul, 11, 2026

87 people who take Actos and Ms contin together, and have interactions are studied.

What are the common drug interactions of Actos and Ms Contin, by gender? *:

female:

Hydrocephalus (water on the brain)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Hypotonia (low muscle tone)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscular weakness (muscle weakness)
Oestrogen receptor assay positive
Pancreatic carcinoma (pancreatic cancer)
Progesterone receptor assay positive
Weight decreased

male:

Emotional distress
Anxiety
Injury
Pleural fibrosis (formation of fibrous tissue in lung)
Constipation
Osteonecrosis of jaw (death of bone of jaw)
Renal failure (kidney dysfunction)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Arthropathy
Fatigue (feeling of tiredness)

What are the common drug interactions of Actos and Ms Contin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

30-39:

Arthralgia (joint pain)
Constipation
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Emotional distress
Glycosylated haemoglobin increased
Grip strength decreased
Joint swelling
Mood altered (changes in mood)
Muscular weakness (muscle weakness)

40-49:

Renal failure (kidney dysfunction)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Breast cancer female
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Oestrogen receptor assay positive
Progesterone receptor assay positive
Acute respiratory failure
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Angina pectoris (chest pain due to ischemia of the heart muscle)

50-59:

Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Cardiac failure congestive
Cauda equina syndrome (affecting the bundle of nerve roots)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Constipation
Cough
Faecal incontinence (a lack of control over passing stool)
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glaucoma (increased fluid pressure in the eye with vision loss)

60+:

Pneumonia
Respiratory disorder (respiratory disease)
Activities of daily living impaired
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ascites (accumulation of fluid in the abdominal cavity)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Confusional state
Cor pulmonale (enlargement of the right ventricle of the heart)
Hypertension (high blood pressure)
Metastases to liver (cancer spreads to liver)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 21 people, 24.14%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 9.20%
Constipation: 6 people, 6.90%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 5.75%
Hepatic Neoplasm Malignant (liver cancer): 5 people, 5.75%

* Approximation only. Some reports may have incomplete information.

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