Actos and Roxicet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actos (pioglitazone hydrochloride) and Roxicet (acetaminophen; oxycodone hydrochloride). Common drug interactions include abdominal pain among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Actos and Roxicet. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Roxicet?

Roxicet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 2,254 Roxicet users. Check the latest studies of Roxicet.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

17 people who take Actos and Roxicet together, and have interactions are studied.

What are the common drug interactions of Actos and Roxicet, by gender? *:

female:

Abdominal pain
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Chronic kidney disease
Diarrhoea
Headache (pain in head)
Pancreatitis (inflammation of pancreas)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Nephrogenic anaemia (anaemia due to kidney disease)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Decreased appetite
Fall
Guillain-barre syndrome (the body's immune system attacks its peripheral nervous system)
International normalised ratio increased
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Pancreatic carcinoma metastatic (pancreatic cancer- metastatic)

What are the common drug interactions of Actos and Roxicet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Diarrhoea
Headache (pain in head)
Pancreatitis (inflammation of pancreas)
Renal injury (kidney injury)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Nephrolithiasis (calculi in the kidneys)
Weight increased

40-49:

n/a

50-59:

Chronic kidney disease
Guillain-barre syndrome (the body's immune system attacks its peripheral nervous system)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Pancreatic carcinoma metastatic (pancreatic cancer- metastatic)
Prostate cancer
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Vomiting
Weight decreased
Weight increased

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 35.29%
Infection: 5 people, 29.41%
High Blood Cholesterol: 5 people, 29.41%
Indigestion: 5 people, 29.41%
Fluid Retention (an abnormal accumulation of fluid in the blood): 4 people, 23.53%
High Blood Pressure: 4 people, 23.53%
Stress And Anxiety: 3 people, 17.65%
General Physical Health Deterioration (weak health status): 3 people, 17.65%
Neuralgia (pain in one or more nerves): 3 people, 17.65%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 3 people, 17.65%

* Approximation only. Some reports may have incomplete information.

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