Acyclovir and Hyzaar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acyclovir (acyclovir) and Hyzaar (hydrochlorothiazide; losartan potassium). Common drug interactions include sinusitis among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Acyclovir and Hyzaar. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Acyclovir?

Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. eHealthMe is studying from 54,961 Acyclovir users. Check the latest studies of Acyclovir.

What is Hyzaar?

Hyzaar has active ingredients of hydrochlorothiazide; losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 16,614 Hyzaar users. Check the latest studies of Hyzaar.

On Jul, 11, 2026

75 people who take Acyclovir and Hyzaar together, and have interactions are studied.

What are the common drug interactions of Acyclovir and Hyzaar, by gender? *:

female:

Sinusitis (inflammation of sinus)
Abdominal pain
Anaemia (lack of blood)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Atelectasis (partial or complete collapse of the lung)
Balance disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cough
Depressed mood
Fluid retention (an abnormal accumulation of fluid in the blood)

male:

Febrile neutropenia (fever with reduced white blood cells)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Jaw disorder (jaw disease)
Poor venous access
Swelling
Fatigue (feeling of tiredness)
Osteonecrosis of jaw (death of bone of jaw)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Drug toxicity
Urinary tract infection

What are the common drug interactions of Acyclovir and Hyzaar, by age (0-1 to 60+)? *:

0-1:

Acute phosphate nephropathy (sudden damage to the kidneys caused by the formation of phosphate crystals)
Blood creatinine increased
Injection site pain
Injection site swelling
Nephrosclerosis (hardening of the kidney due to renovascular disease)
Renal disorder (kidney disease)
Renal failure chronic (long lasting kidney dysfunction)
Viral pharyngitis (inflammation of the throat or pharynx caused by viral infection)

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Bacterial infection
Bone disorder
Cataract (clouding of the lens inside the eye)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Exostosis (formation of new bone on the surface of a bone)
Fistula (an abnormal connection or passageway between two)
Fistula discharge (discharge from abnormal passage of structure/organ)

30-39:

Multiple drug overdose

40-49:

Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic failure (liver failure)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

50-59:

Swelling
Osteonecrosis of jaw (death of bone of jaw)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Colonic polyp (extra part of colon tissue grow in intestine)
Dental care
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Headache (pain in head)
Insomnia (sleeplessness)
Tooth extraction
Abnormal dreams

60+:

Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)
Bone marrow failure
Chronic lymphocytic leukaemia transformation (white blood cell cancer changes in fast growing cancer in lymph node)
Coombs positive haemolytic anaemia
Cytomegalovirus infection
Dizziness
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Accidental needle stick

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 21 people, 28.00%
Depression: 8 people, 10.67%
Prostate Cancer Metastatic: 7 people, 9.33%
Metastases To Bone (cancer spreads to bone): 7 people, 9.33%
Immunodeficiency Common Variable: 6 people, 8.00%
Central Nervous System Lymphoma (cancer of central nervous system forms in lymph tissue): 6 people, 8.00%
Joint Pain: 4 people, 5.33%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 5.33%

* Approximation only. Some reports may have incomplete information.

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