Acyclovir and Nexavar drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Acyclovir (acyclovir) and Nexavar (sorafenib tosylate). Common drug interactions include skin cancer among females and death among males.
The phase IV clinical study analyzes what interactions people have when they take Acyclovir and Nexavar. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.
What is Acyclovir?
Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. eHealthMe is studying from 54,961 Acyclovir users. Check the latest studies of Acyclovir.
What is Nexavar?
Nexavar has active ingredients of sorafenib tosylate. It is often used in hepatocellular carcinoma. eHealthMe is studying from 23,250 Nexavar users. Check the latest studies of Nexavar.
44 people who take Acyclovir and Nexavar together, and have interactions are studied.

What are the common drug interactions of Acyclovir and Nexavar, by gender? *:
female:
- Skin cancer
- Accident
- Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
- Back pain
- Diarrhoea
- Drug ineffective
- Dry mouth
- Oral pain
- Abdominal pain
- Activated partial thromboplastin time prolonged
male:
- Death
- Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
- Anxiety
- Ascites (accumulation of fluid in the abdominal cavity)
- Bladder cancer
- Bone disorder
- Cellulitis (infection under the skin)
- Colostomy
- Compression fracture (fracture due to pressure caused by injury)
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
What are the common drug interactions of Acyclovir and Nexavar, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
- Dizziness
- Febrile neutropenia (fever with reduced white blood cells)
- Pyrexia (fever)
- Vomiting
- Accident
- Back pain
- Diarrhoea
- Drug ineffective
- Headache (pain in head)
- Pruritus (severe itching of the skin)
20-29:
n/a
30-39:
n/a
40-49:
- Pyrexia (fever)
- Acidosis (build-up of carbon dioxide in the blood)
- Cancer pain
- Constipation
- Erythema (redness of the skin)
- General physical health deterioration (weak health status)
- Hypertension (high blood pressure)
- Nausea (feeling of having an urge to vomit)
- Oropharyngeal pain
- Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
50-59:
- Blood bilirubin increased
- Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
- Cachexia (loss of weight)
- Coagulopathy (blood's ability to clot is impaired)
- Colitis (inflammation of colon)
- Coma hepatic (accumulation in the bloodstream of toxic substances that are normally removed by the liver leads coma)
- Confusional state
- Dehydration (dryness resulting from the removal of water)
- Dementia (madness)
- Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
60+:
- Pain
- Death
- Cellulitis (infection under the skin)
- Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
- Colostomy
- Compression fracture (fracture due to pressure caused by injury)
- Decreased interest
- Dehydration (dryness resulting from the removal of water)
- Dizziness
- Dyspnoea (difficult or laboured respiration)
What are the existing conditions these people have? *
- Hepatic Neoplasm Malignant (liver cancer): 14 people, 31.82%
- Renal Cell Carcinoma (a kidney cancer): 10 people, 22.73%
- Pain: 10 people, 22.73%
- High Blood Pressure: 9 people, 20.45%
- Constipation: 9 people, 20.45%
- Incision Site Pain: 8 people, 18.18%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 18.18%
- Metastases To Bone (cancer spreads to bone): 7 people, 15.91%
- Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 6 people, 13.64%
- Sinusitis (inflammation of sinus): 5 people, 11.36%
* Approximation only. Some reports may have incomplete information.
Do you take Acyclovir and Nexavar?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Acyclovir and Nexavar:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Acyclovir:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Nexavar:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Acyclovir and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Nexavar and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .
- Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .
How the study uses the data?
The study uses data from the FDA. It is based on acyclovir and sorafenib tosylate (the active ingredients of Acyclovir and Nexavar, respectively), and Acyclovir and Nexavar (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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