Acyclovir and Silvadene drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acyclovir (acyclovir) and Silvadene (silver sulfadiazine). Common drug interactions include extrapyramidal disorder among females and agitation among males.

The phase IV clinical study analyzes what interactions people have when they take Acyclovir and Silvadene. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Acyclovir?

Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. eHealthMe is studying from 54,961 Acyclovir users. Check the latest studies of Acyclovir.

What is Silvadene?

Silvadene has active ingredients of silver sulfadiazine. eHealthMe is studying from 1,161 Silvadene users. Check the latest studies of Silvadene.

On Jul, 26, 2026

19 people who take Acyclovir and Silvadene together, and have interactions are studied.

Acyclovir and Silvadene drug interactions.

What are the common drug interactions of Acyclovir and Silvadene, by gender? *:

female:

Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Eye haemorrhage (bleeding in the eye)
Fall
Fungal infection
Gait disturbance
Gastroenteritis (inflammation of stomach and intestine)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Generalised oedema (swelling all over the body)
Genital abscess (build up of pus in genital)
Headache (pain in head)

male:

Agitation (state of anxiety or nervous excitement)
Confusional state
Respiratory failure (inadequate gas exchange by the respiratory system)
Staphylococcal infection (an infection with staphylococcus bacteria)
Urinary hesitation (difficulty in beginning the flow of urine)
Bacterial infection
Blood culture positive
Diarrhoea
Eye infection
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)

What are the common drug interactions of Acyclovir and Silvadene, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Osteomyelitis (infection of bone)
Psychotic disorder

30-39:

n/a

40-49:

Cellulitis (infection under the skin)
Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
Gangrene (body tissue dies)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Vulval abscess
Vulval cellulitis (inflammation of skin around vagina)
Vulvitis (inflammation of the vulva)

50-59:

n/a

60+:

Agitation (state of anxiety or nervous excitement)
Confusional state
Respiratory failure (inadequate gas exchange by the respiratory system)
Staphylococcal infection (an infection with staphylococcus bacteria)
Urinary hesitation (difficulty in beginning the flow of urine)
Bacterial infection
Blood culture positive
Constipation
Diarrhoea
Eye infection

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 4 people, 21.05%
Multiple Myeloma (cancer of the plasma cells): 4 people, 21.05%
Nausea (feeling of having an urge to vomit): 3 people, 15.79%
Pain: 2 people, 10.53%
High Blood Pressure: 2 people, 10.53%
Joint Pain: 2 people, 10.53%
Weight Decreased: 2 people, 10.53%
Hypotension (abnormally low blood pressure): 2 people, 10.53%
Type 2 Diabetes: 2 people, 10.53%
Stress And Anxiety: 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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