Acyclovir and Trikafta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acyclovir (acyclovir) and Trikafta (elexacaftor, ivacaftor, tezacaftor; ivacaftor). Common drug interactions include decreased appetite among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Acyclovir and Trikafta. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Acyclovir?

Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. eHealthMe is studying from 54,961 Acyclovir users. Check the latest studies of Acyclovir.

What is Trikafta?

Trikafta has active ingredients of elexacaftor, ivacaftor, tezacaftor; ivacaftor. eHealthMe is studying from 11,852 Trikafta users. Check the latest studies of Trikafta.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

17 people who take Acyclovir and Trikafta together, and have interactions are studied.

Acyclovir and Trikafta drug interactions.

What are the common drug interactions of Acyclovir and Trikafta, by gender? *:

female:

Decreased appetite
Pain
Blood sodium decreased
Contusion (a type of hematoma of tissue in which capillaries)
Dehydration (dryness resulting from the removal of water)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Overdose
Pyrexia (fever)
Spinal fracture (fracture in one of vertebrae)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)

male:

Abdominal pain upper

What are the common drug interactions of Acyclovir and Trikafta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Asthenia (weakness)
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Decreased appetite
Dizziness
Fatigue (feeling of tiredness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hepatic enzyme increased
Hepatic failure (liver failure)
Irritability

30-39:

Depression
Haemorrhagic ovarian cyst (bleeding ovarian cyst)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Loss of consciousness
Nausea (feeling of having an urge to vomit)
Premature menopause
Pruritus (severe itching of the skin)
Rash pruritic (redness with itching)
Weight increased
Anxiety

40-49:

n/a

50-59:

Abdominal pain upper
Acute respiratory failure
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Infection
Rehabilitation therapy

60+:

n/a

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 14 people, 82.35%
Cystic Fibrosis Lung (fibrosis with cyst in the lung): 4 people, 23.53%
Broken Bone: 3 people, 17.65%
Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 1 person, 5.88%
Bacterial Infection: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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