Acyclovir and Xyzal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acyclovir (acyclovir) and Xyzal (levocetirizine dihydrochloride). Common drug interactions include weight fluctuation among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Acyclovir and Xyzal. It is created by eHealthMe based on reports of 99 people who take the same drugs from the FDA, and is updated regularly.

What is Acyclovir?

Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. eHealthMe is studying from 54,961 Acyclovir users. Check the latest studies of Acyclovir.

What is Xyzal?

Xyzal has active ingredients of levocetirizine dihydrochloride. It is often used in allergies. eHealthMe is studying from 21,479 Xyzal users. Check the latest studies of Xyzal.

On Aug, 11, 2026

99 people who take Acyclovir and Xyzal together, and have interactions are studied.

What are the common drug interactions of Acyclovir and Xyzal, by gender? *:

female:

Weight fluctuation
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back disorder
Back pain
Blood pressure orthostatic
Bowel movement irregularity
Breath holding
Cardiac disorder
Chest discomfort
Chest pain

male:

Pneumonia
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Cytolytic hepatitis (dissolution or destruction of a liver cell)
Drug intolerance (drug sensitivity)
Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Dyspnoea (difficult or laboured respiration)
Encephalitis (inflammation of the brain)
Fatigue (feeling of tiredness)
Gamma-glutamyltransferase increased
Listeriosis (a food borne illness caused by listeria monocytogenes, bacteria found in soil and water)

What are the common drug interactions of Acyclovir and Xyzal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Diarrhoea
Flatulence (flatus expelled through the anus)
Abdominal distension
Fungal infection
Moaning (a low, sustained, mournful cry)
Urinary tract infection
Constipation
Aerophagia (excessive air swallowing)
Crying
Drug ineffective

30-39:

Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Anxiety
Crying
Depression
Dizziness
Drug hypersensitivity
Fatigue (feeling of tiredness)
Hallucination (an experience involving the perception of something not present)
Headache (pain in head)
Insomnia (sleeplessness)

40-49:

Ankle fracture
Craniocerebral injury (injury to cranium and brain)
Ligament sprain (ligament stretched)
Multiple fractures
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Panic attack
Parathyroid disorder
Sinusitis (inflammation of sinus)
Upper respiratory tract infection

50-59:

Dyspnoea (difficult or laboured respiration)
Emotional distress
Pain
Productive cough
Cholangitis (infection of the bile duct)
Acute generalised exanthematous pustulosis (acute febrile drug eruption)
Arthralgia (joint pain)
Aspartate aminotransferase increased
Back pain
Bone density decreased

60+:

Pneumonia
Neutropenia (an abnormally low number of neutrophils)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Aspartate aminotransferase increased
Back pain
Blood creatinine increased
Blood pressure increased
C-reactive protein increased
Cardiac failure chronic

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 24 people, 24.24%
Immunodeficiency Common Variable: 15 people, 15.15%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 8.08%
High Blood Pressure: 8 people, 8.08%
Type 2 Diabetes: 6 people, 6.06%
Hypersensitivity: 6 people, 6.06%
Constipation: 5 people, 5.05%

* Approximation only. Some reports may have incomplete information.

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