Aczone and Retin-a drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aczone (dapsone) and Retin-a (tretinoin). Common drug interactions include dizziness among females and pruritus among males.

The phase IV clinical study analyzes what interactions people have when they take Aczone and Retin-a. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Aczone?

Aczone has active ingredients of dapsone. It is often used in acne. eHealthMe is studying from 1,152 Aczone users. Check the latest studies of Aczone.

What is Retin-a?

Retin-a has active ingredients of tretinoin. It is often used in acne. eHealthMe is studying from 2,475 Retin-a users. Check the latest studies of Retin-a.

On Aug, 04, 2026

34 people who take Aczone and Retin-a together, and have interactions are studied.

What are the common drug interactions of Aczone and Retin-A, by gender? *:

female:

Dizziness
Rash
Back pain
Ocular rosacea (redness, irritation or burning of the eyes)
Pain
Burning sensation
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Erythema (redness of the skin)
Eye swelling

male:

Pruritus (severe itching of the skin)
Depression
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Nodule (a growth of abnormal tissue)
Pain
Pyrexia (fever)
Sinusitis (inflammation of sinus)
Stomatitis (inflammation of mucous membrane of mouth)
Stress

What are the common drug interactions of Aczone and Retin-A, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pruritus (severe itching of the skin)
Acne cystic (skin problems that cause pimples)
Back pain
Chest pain
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Eye swelling
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Inflammation
Myalgia (muscle pain)

20-29:

Depression
Suicidal ideation
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Stomatitis (inflammation of mucous membrane of mouth)
Surgery

30-39:

Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Rash
Throat irritation
Abortion induced (medically referred abortion)
Blood potassium decreased
Dizziness
Gait disturbance
Muscular weakness (muscle weakness)

40-49:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Acne cystic (skin problems that cause pimples)
Application site discolouration
Scratch
Skin exfoliation (removal of the oldest dead skin cells)
Therapeutic response decreased (less preventive response)

50-59:

Dizziness
Joint swelling
Nausea (feeling of having an urge to vomit)
Peripheral swelling
Rash
Burning sensation
Erythema (redness of the skin)
Eye swelling
Abdominal pain upper

60+:

Dyspepsia (indigestion)
Increased appetite
Pruritus (severe itching of the skin)
Thrombosis (formation of a blood clot inside a blood vessel)
Vulvovaginal dryness
White blood cell count decreased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 23.53%
Insomnia (sleeplessness): 4 people, 11.76%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 8.82%
Asthma: 3 people, 8.82%
Skin Wrinkling (wrinkle on skin): 2 people, 5.88%
Rashes (redness): 2 people, 5.88%
Drowsiness: 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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