Adalat and Evoxac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adalat (nifedipine) and Evoxac (cevimeline hydrochloride). Common drug interactions include abdominal pain upper among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Adalat and Evoxac. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Adalat?

Adalat has active ingredients of nifedipine. It is often used in high blood pressure. eHealthMe is studying from 20,940 Adalat users. Check the latest studies of Adalat.

What is Evoxac?

Evoxac has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 2,028 Evoxac users. Check the latest studies of Evoxac.

On Jul, 13, 2026

13 people who take Adalat and Evoxac together, and have interactions are studied.

What are the common drug interactions of Adalat and Evoxac, by gender? *:

female:

Abdominal pain upper
Pleural effusion (water on the lungs)
Pulmonary oedema (fluid accumulation in the lungs)
Joint swelling
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Blood alkaline phosphatase increased
Blood creatinine increased
Cardiac tamponade (fluid accumulates in heart covering)
Decreased appetite
Gamma-glutamyltransferase increased

male:

Death

What are the common drug interactions of Adalat and Evoxac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood alkaline phosphatase increased
Blood creatinine increased
Cardiac tamponade (fluid accumulates in heart covering)
Decreased appetite
Gamma-glutamyltransferase increased
Nephrogenic anaemia (anaemia due to kidney disease)
Platelet count decreased
Renal failure chronic (long lasting kidney dysfunction)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Biliary cirrhosis primary (primary biliary cirrhosis (pbc) is a long-term liver disease that damages the small bile ducts in the liver. the build-up of bile damages the liver)

50-59:

Cheilitis (infection of lips)
Lip oedema (swelling of lip)
Mass

60+:

Abdominal pain upper
Arthralgia (joint pain)
Pulmonary oedema (fluid accumulation in the lungs)
Joint swelling
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Death
Abdominal pain lower
Asthenia (weakness)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Drug ineffective

What are the existing conditions these people have? *

Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 5 people, 38.46%
Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 2 people, 15.38%
Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 2 people, 15.38%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 1 person, 7.69%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 7.69%
Micturition Urgency (urgency to pass the urine): 1 person, 7.69%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 7.69%
Hypoglycemia (low blood sugar): 1 person, 7.69%
Hyperglycemia (high blood sugar): 1 person, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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