Adcirca and Actonel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adcirca (tadalafil) and Actonel (risedronate sodium). Common drug interactions include viral infection among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Adcirca and Actonel. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

On Jul, 12, 2026

77 people who take Adcirca and Actonel together, and have interactions are studied.

What are the common drug interactions of Adcirca and Actonel, by gender? *:

female:

Viral infection
Cardiac failure
Hypokalaemia (low potassium)
Platelet count decreased
Stomatitis (inflammation of mucous membrane of mouth)
Headache (pain in head)
Fatigue (feeling of tiredness)
Peripheral swelling
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Oedema peripheral (superficial swelling)

male:

Death
Acute respiratory failure
Lung neoplasm malignant (cancer tumour of lung)
Pneumonia
Renal failure acute (rapid kidney dysfunction)
Rib fracture
Septic shock (shock due to blood infection)
Cardiac arrest
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)

What are the common drug interactions of Adcirca and Actonel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Headache (pain in head)
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Diarrhoea
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Hyperglycaemia (high blood sugar)
Peripheral coldness
Rash
Abdominal pain upper
Atrial tachycardia (rhythm disturbance that arises in the atria)
Sepsis (a severe blood infection that can lead to organ failure and death)

30-39:

Headache (pain in head)
Abdominal pain upper
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Atrial tachycardia (rhythm disturbance that arises in the atria)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Alopecia (absence of hair from areas of the body)
Malaise (a feeling of general discomfort or uneasiness)
Palpitations (feelings or sensations that your heart is pounding or racing)

40-49:

Hypotension (abnormally low blood pressure)
Rash macular (small, flat red spots)
Urticaria (rash of round, red welts on the skin that itch intensely)
Diarrhoea
Myalgia (muscle pain)
Pain in extremity
Anaemia (lack of blood)
Arthralgia (joint pain)
Chest discomfort
Complement factor decreased

50-59:

Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Melaena (the passage of black, tarry stools)
Renal impairment (severely reduced kidney function)
Right ventricular failure (right half of the heart fails to work)
Concomitant disease progression (progress in accompanying disease)
Death
Lung neoplasm malignant (cancer tumour of lung)

60+:

Fatigue (feeling of tiredness)
Peripheral swelling
Nasal discharge discolouration (change in colour of nasal discharge)
Nasopharyngitis (inflammation of the nasopharynx)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Phlebitis (inflammation of the walls of a vein)
Poor venous access
Skin discolouration (change of skin colour)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Tooth disorder (tooth disease)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 57 people, 74.03%
Mixed Connective Tissue Disease (an autoimmune disease, in which the body's defence system attacks itself): 11 people, 14.29%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 9 people, 11.69%
Arrhythmias (irregular heartbeat): 9 people, 11.69%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 6.49%
Skin Ulcer: 4 people, 5.19%
Rashes (redness): 4 people, 5.19%
Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 4 people, 5.19%
Hyperglycemia (high blood sugar): 4 people, 5.19%

* Approximation only. Some reports may have incomplete information.

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