Adcirca and Cyclophosphamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adcirca (tadalafil) and Cyclophosphamide (cyclophosphamide). Common drug interactions include oedema among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Adcirca and Cyclophosphamide. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

What is Cyclophosphamide?

Cyclophosphamide has active ingredients of cyclophosphamide. It is often used in multiple myeloma. eHealthMe is studying from 185,240 Cyclophosphamide users. Check the latest studies of Cyclophosphamide.

On Jul, 10, 2026

48 people who take Adcirca and Cyclophosphamide together, and have interactions are studied.

Adcirca and Cyclophosphamide drug interactions.

What are the common drug interactions of Adcirca and Cyclophosphamide, by gender? *:

female:

Oedema (fluid collection in tissue)
White blood cell count decreased
Anaemia (lack of blood)
Diarrhoea
Cytomegalovirus infection
Oedema peripheral (superficial swelling)
Hypertension (high blood pressure)
Urinary tract infection
Pulmonary vein occlusion (blockage in pulmonary vein)
Respiratory disorder (respiratory disease)

male:

Diarrhoea
Bronchitis bacterial (inflammation of the mucous membrane in the bronchial tubes due to bacterial infection)
Hospitalisation
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Multi-organ failure (multisystem organ failure)
Neutropenia (an abnormally low number of neutrophils)
Pneumonia
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Right ventricular failure (right half of the heart fails to work)

What are the common drug interactions of Adcirca and Cyclophosphamide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Gait disturbance
Memory impairment
Acute respiratory distress syndrome
Fall
Pelvic fracture
Respiratory failure (inadequate gas exchange by the respiratory system)
Speech disorder
Asthma

10-19:

Cystitis haemorrhagic (blood in the urine and painful voiding)
Blood urine present
Suprapubic pain

20-29:

Nausea (feeling of having an urge to vomit)
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot)
Blood potassium increased
Cardiogenic shock (inadequate circulation of blood)
Drug intolerance (drug sensitivity)
Multi-organ failure (multisystem organ failure)
Pneumonia
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Right ventricular failure (right half of the heart fails to work)

30-39:

Headache (pain in head)
Anaemia (lack of blood)
Abdominal pain upper
Atrial tachycardia (rhythm disturbance that arises in the atria)
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Abdominal distension
Decreased appetite

40-49:

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

50-59:

Diarrhoea
Skin ulcer
Bronchitis bacterial (inflammation of the mucous membrane in the bronchial tubes due to bacterial infection)
Liver disorder (liver diseases)
Nausea (feeling of having an urge to vomit)
Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Hot flush (sudden feelings of heat)
Interstitial lung disease
Pain
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)

60+:

Oedema (fluid collection in tissue)
White blood cell count decreased
Ascites (accumulation of fluid in the abdominal cavity)
Back pain
Bacterial infection
Blood creatinine increased
Cardiac failure
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hypokalaemia (low potassium)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 40 people, 83.33%
Mixed Connective Tissue Disease (an autoimmune disease, in which the body's defence system attacks itself): 14 people, 29.17%
Takayasu's Arteritis (an inflammation of the aorta -- the artery that carries blood from the heart to the rest of the body): 7 people, 14.58%
High Blood Pressure: 7 people, 14.58%
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 6 people, 12.50%
Lumbar Spinal Stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone): 6 people, 12.50%
Pleural Effusion (water on the lungs): 3 people, 6.25%
Interstitial Lung Disease: 3 people, 6.25%
Cardiac Failure: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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