Adcirca and Fentanyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adcirca (tadalafil) and Fentanyl (fentanyl citrate). Common drug interactions include orthostatic hypotension among females and acute respiratory distress syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Adcirca and Fentanyl. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

On Aug, 07, 2026

62 people who take Adcirca and Fentanyl together, and have interactions are studied.

What are the common drug interactions of Adcirca and Fentanyl, by gender? *:

female:

Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Rash
Spinal disorder (disease of spine a back bone)
Thyroid neoplasm (tumour of thyroid)
White blood cell count decreased
Wound dehiscence (a surgical incision reopens either internally or externally)
Abdominal pain lower
Catheter site infection (infection at the site of insertion)
Drug abuse
Hepatomegaly (abnormal enlargement of the liver)

male:

Acute respiratory distress syndrome
Blood urine present
Weight decreased
White blood cell count decreased
Dizziness
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)
Acute respiratory failure
Cor pulmonale (enlargement of the right ventricle of the heart)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Adcirca and Fentanyl, by age (0-1 to 60+)? *:

0-1:

Anaemia (lack of blood)
Catheter site erythema (redness of skin at catheter site)
Chylothorax (collection of lymph fluid around the lung)
Diarrhoea
Erythema (redness of the skin)
Hypokalaemia (low potassium)
Mediastinitis (inflammation of the tissues in the mid-chest)
Pericardial effusion (fluid around the heart)
Rash
Rhinorrhoea (watery mucus discharge from the nose)

2-9:

Pyrexia (fever)
Hypotension (abnormally low blood pressure)
Upper respiratory tract inflammation
Cough
Vomiting
Abdominal pain
Rhinorrhoea (watery mucus discharge from the nose)
Diarrhoea
Cardiac failure
Acute respiratory distress syndrome

10-19:

Device related infection
Diarrhoea
Headache (pain in head)
Nasopharyngitis (inflammation of the nasopharynx)
Platelet count decreased
Procedural pain
Procedural vomiting
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting
Cough

20-29:

Pulmonary alveolar haemorrhage (acute bleeding)
Abdominal distension
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Aspartate aminotransferase increased
Atelectasis (partial or complete collapse of the lung)
Bacillus infection
Blood alkaline phosphatase increased
Blood bilirubin increased
Constipation

30-39:

Asthenia (weakness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest pain
Decreased activity
Dyspnoea (difficult or laboured respiration)
Fear
Gait disturbance
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hypersomnia (excessive daytime sleepiness (eds))
Lung disorder (lung disease)

40-49:

Lymphoma (cancer that begins in immune system cells)
Abdominal pain lower
Chills (felling of cold)
Drug abuse
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Headache (pain in head)
Hepatomegaly (abnormal enlargement of the liver)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pain
International normalised ratio increased

50-59:

Death
Dyspnoea (difficult or laboured respiration)

60+:

Oedema peripheral (superficial swelling)
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Fall
Fatigue (feeling of tiredness)
Femur fracture
Fluid overload (too much fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemoglobin decreased
Hip fracture

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 47 people, 75.81%
Sedation: 4 people, 6.45%
Hypokalemia (low potassium): 4 people, 6.45%
Depression: 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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