Adcirca and Inspra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adcirca (tadalafil) and Inspra (eplerenone). Common drug interactions include blood creatinine increased among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Adcirca and Inspra. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

What is Inspra?

Inspra has active ingredients of eplerenone. It is often used in high blood pressure. eHealthMe is studying from 3,510 Inspra users. Check the latest studies of Inspra.

On Jul, 31, 2026

63 people who take Adcirca and Inspra together, and have interactions are studied.

What are the common drug interactions of Adcirca and Inspra, by gender? *:

female:

Blood creatinine increased
Blood urea increased
Brain natriuretic peptide increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Concomitant disease progression (progress in accompanying disease)
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Diarrhoea
Dizziness

male:

Dyspnoea (difficult or laboured respiration)
Oedema peripheral (superficial swelling)
Nausea (feeling of having an urge to vomit)
Pain in jaw
Tremor (trembling or shaking movements in one or more parts of your body)
Cardiac failure congestive
Fluid overload (too much fluid in the blood)
Hypoxia (low oxygen in tissues)
Myalgia (muscle pain)
Oedema (fluid collection in tissue)

What are the common drug interactions of Adcirca and Inspra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arterial injury

40-49:

Headache (pain in head)
Intestinal perforation (complete penetration of the wall of the intestine)
Septic shock (shock due to blood infection)

50-59:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Concomitant disease progression (progress in accompanying disease)
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dizziness
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Eustachian tube disorder (inflammation of the middle ear, commonly affects the eustachian tube)

60+:

Cardiac failure
Respiratory syncytial virus infection (viral disease of respiratory system)
Nausea (feeling of having an urge to vomit)
Pain in jaw
Tremor (trembling or shaking movements in one or more parts of your body)
Asthenia (weakness)
Cardiac failure congestive
Fluid overload (too much fluid in the blood)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hypoxia (low oxygen in tissues)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 28 people, 44.44%
Nausea (feeling of having an urge to vomit): 5 people, 7.94%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 6.35%

* Approximation only. Some reports may have incomplete information.

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