Adcirca and Pentoxifylline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adcirca (tadalafil) and Pentoxifylline (pentoxifylline). Common drug interactions include headache among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Adcirca and Pentoxifylline. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

What is Pentoxifylline?

Pentoxifylline has active ingredients of pentoxifylline. eHealthMe is studying from 5,997 Pentoxifylline users. Check the latest studies of Pentoxifylline.

On Jul, 13, 2026

27 people who take Adcirca and Pentoxifylline together, and have interactions are studied.

Adcirca and Pentoxifylline drug interactions.

What are the common drug interactions of Adcirca and Pentoxifylline, by gender? *:

female:

Headache (pain in head)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Pneumonia
Chest pain
Cell death
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Fatigue (feeling of tiredness)
International normalised ratio increased
Pain

male:

Pneumonia
Death
Aortic valve disease
Aortic valve replacement
Cardiac failure
Dyspnoea (difficult or laboured respiration)
Presyncope
Rash
Rash erythematous (redness of the skin)
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the common drug interactions of Adcirca and Pentoxifylline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chest pain
Fatigue (feeling of tiredness)
Headache (pain in head)
Palpitations (feelings or sensations that your heart is pounding or racing)
Dyspnoea (difficult or laboured respiration)
Fluid retention (an abnormal accumulation of fluid in the blood)

40-49:

Death

50-59:

Peripheral swelling

60+:

Headache (pain in head)
Pneumonia
Vomiting
Walking disability
Anxiety
Aortic valve disease
Aortic valve replacement
Cardiac failure
Cardiopulmonary failure (cessation of normal circulation of the blood due to failure of the heart to contract)
Death

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 17 people, 62.96%
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases): 2 people, 7.41%
Pain: 2 people, 7.41%
Insomnia (sleeplessness): 2 people, 7.41%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 2 people, 7.41%
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble): 2 people, 7.41%
Cor Pulmonale Chronic (long lasting enlargement of the right ventricle of the heart): 2 people, 7.41%
Cardiac Failure: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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