Adcirca and Sodium bicarbonate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adcirca (tadalafil) and Sodium bicarbonate (sodium bicarbonate). Common drug interactions include dyspnoea among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Adcirca and Sodium bicarbonate. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

What is Sodium bicarbonate?

Sodium bicarbonate has active ingredients of sodium bicarbonate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 27,283 Sodium bicarbonate users. Check the latest studies of Sodium bicarbonate.

On Jul, 14, 2026

41 people who take Adcirca and Sodium bicarbonate together, and have interactions are studied.

Adcirca and Sodium bicarbonate drug interactions.

What are the common drug interactions of Adcirca and Sodium Bicarbonate, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Vomiting
Pain
Diarrhoea
Pyrexia (fever)
Chest pain
Dizziness
Depressed level of consciousness
Abdominal pain upper

male:

Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Arrhythmia (irregular heartbeat)
Death
Fluid retention (an abnormal accumulation of fluid in the blood)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Right ventricular failure (right half of the heart fails to work)

What are the common drug interactions of Adcirca and Sodium Bicarbonate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Cardiac failure
Overdose
Respiratory failure (inadequate gas exchange by the respiratory system)

10-19:

Dyspnoea (difficult or laboured respiration)
Arrhythmia (irregular heartbeat)
Chronic kidney disease
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Device occlusion
Dizziness
Dysphonia (speech disorder attributable to a disorder of phonation)
Ear pain
Fluid retention (an abnormal accumulation of fluid in the blood)
Headache (pain in head)

20-29:

Anaemia of chronic disease
Blood culture positive
Cardiac murmur (an heart sound in valve abnormality)
Catheter site infection (infection at the site of insertion)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Cough
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Influenza
Mycobacterium avium complex infection

30-39:

n/a

40-49:

Diarrhoea
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Vomiting
Weight increased

50-59:

Pain
Pain in jaw
Pyrexia (fever)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Scleroderma (hard skin)
Vision blurred
Weight decreased
Wheezing (a high-pitched whistling sound made while you breath)
Diarrhoea

60+:

Nausea (feeling of having an urge to vomit)
Dyspnoea (difficult or laboured respiration)
Anaemia (lack of blood)
Cellulitis (infection under the skin)
Contusion (a type of hematoma of tissue in which capillaries)
Gait disturbance
Haemoglobin decreased
Joint swelling
Localised infection (infection at the single location)
Pyrexia (fever)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 28 people, 68.29%
Pain: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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