Adderall 5 and Oxycontin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adderall 5 (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) and Oxycontin (oxycodone hydrochloride). Common drug interactions include headache among females and anger among males.

The phase IV clinical study analyzes what interactions people have when they take Adderall 5 and Oxycontin. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Adderall 5?

Adderall 5 has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 2,997 Adderall 5 users. Check the latest studies of Adderall 5.

What is Oxycontin?

Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 212,533 Oxycontin users. Check the latest studies of Oxycontin.



On Jul, 05, 2026

27 people who take Adderall 5 and Oxycontin together, and have interactions are studied.

Adderall 5 and Oxycontin drug interactions.

What are the common drug interactions of Adderall 5 and Oxycontin, by gender? *:

female:

  1. Headache (pain in head)
  2. Hydropneumothorax (presence of both air and fluid in the pleural space (lungs))
  3. Hyperaesthesia
  4. Hypoaesthesia (reduced sense of touch or sensation)
  5. Injury
  6. Injury corneal
  7. Insomnia (sleeplessness)
  8. Intercostal neuralgia (inflammation of the intercostal nerves)
  9. Intervertebral disc degeneration (spinal disc degeneration)
  10. Laceration (tearing of soft body tissue)

male:

  1. Anger
  2. Anxiety
  3. Feeling of despair
  4. General physical health deterioration (weak health status)
  5. Hostility
  6. Hyperhidrosis (abnormally increased sweating)
  7. Impaired driving ability
  8. Impaired reasoning
  9. Injury
  10. Insomnia (sleeplessness)

What are the common drug interactions of Adderall 5 and Oxycontin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Death
  2. Depressed level of consciousness
  3. Drug abuse
  4. Drug administration error
  5. Headache (pain in head)
  6. Unresponsive to stimuli

20-29:

n/a

30-39:

  1. Arthralgia (joint pain)
  2. Fatigue (feeling of tiredness)
  3. Joint stiffness
  4. Rhinorrhoea (watery mucus discharge from the nose)

40-49:

  1. Anger
  2. Anxiety
  3. Brain injury
  4. Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
  5. Confusional state
  6. Dizziness
  7. Drug dependence
  8. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  9. Emotional disorder
  10. Emotional distress

50-59:

  1. Anxiety
  2. Blood calcium decreased
  3. Irritable bowel syndrome
  4. Pain in extremity
  5. Tremor (trembling or shaking movements in one or more parts of your body)
  6. Ankle fracture
  7. Nausea (feeling of having an urge to vomit)
  8. Abdominal pain upper
  9. Abscess (pus)
  10. Allodynia (a condition in which pain is caused by a stimulus that does not normally elicit pain)

60+:

  1. Anxiety
  2. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  3. Bruxism (habitual grinding of the teeth, typically during sleep)
  4. Dysarthria (speech disorder)
  5. Dyskinesia (abnormality or impairment of voluntary movement)
  6. Gait disturbance
  7. Speech disorder
  8. Tardive dyskinesia (a disorder that involves involuntary movements)
  9. Tooth loss
  10. Trismus (reduced opening of the jaws)

What are the existing conditions these people have? *

  1. Insomnia (sleeplessness): 7 people, 25.93%
  2. Sleep Disorder: 6 people, 22.22%
  3. Bone Density Abnormal: 6 people, 22.22%
  4. Stress And Anxiety: 3 people, 11.11%
  5. Osteoporosis (bones weak and more likely to break): 3 people, 11.11%
  6. Muscle Spasms (muscle contraction): 3 people, 11.11%
  7. Quit Smoking: 2 people, 7.41%
  8. Back Pain: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Adderall 5 and Oxycontin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Adderall 5:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Oxycontin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Adderall 5 and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Oxycontin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate and oxycodone hydrochloride (the active ingredients of Adderall 5 and Oxycontin, respectively), and Adderall 5 and Oxycontin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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