Adderall 5 and Vicodin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adderall 5 (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) and Vicodin (acetaminophen; hydrocodone bitartrate). Common drug interactions include renal failure acute among females and activities of daily living impaired among males.

The phase IV clinical study analyzes what interactions people have when they take Adderall 5 and Vicodin. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Adderall 5?

Adderall 5 has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 2,997 Adderall 5 users. Check the latest studies of Adderall 5.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

On Jul, 08, 2026

52 people who take Adderall 5 and Vicodin together, and have interactions are studied.

Adderall 5 and Vicodin drug interactions.

What are the common drug interactions of Adderall 5 and Vicodin, by gender? *:

female:

Renal failure acute (rapid kidney dysfunction)
Retching (strong involuntary effort to vomit)
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
Rib fracture
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Sinusitis (inflammation of sinus)
Tendon rupture (tear of tendon)
Thoracic vertebral fracture
Tooth disorder (tooth disease)
Tooth fracture

male:

Activities of daily living impaired
Agitation (state of anxiety or nervous excitement)
Erectile dysfunction
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hyperhidrosis (abnormally increased sweating)
Influenza like illness
Lethargy (tiredness)
Mood swings (an extreme or rapid change in mood)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Right ventricular failure (right half of the heart fails to work)

What are the common drug interactions of Adderall 5 and Vicodin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anxiety
Emotional distress
Cholecystitis chronic (long lasting infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gallbladder disorder
Pancreatitis (inflammation of pancreas)
Pulmonary embolism (blockage of the main artery of the lung)
Sphincter of oddi dysfunction (dysfunction of a muscular valve that controls the flow of digestive juices)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Dyspnoea (difficult or laboured respiration)

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Fatigue (feeling of tiredness)
Pregnancy
Pulmonary embolism (blockage of the main artery of the lung)
Weight increased
Anxiety
Cerebral venous thrombosis (clot in brains venous blood system)
Emotional distress
Arrhythmia (irregular heartbeat)

30-39:

Vomiting
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Anxiety
Arterial thrombosis (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system)
Arthralgia (joint pain)
Candidiasis (candidiasis or thrush is a fungal infection)
Cardiac arrest
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dysarthria (speech disorder)

40-49:

Gait disturbance
Immune reconstitution syndrome (immune recovery syndrome)
Leukocytosis (increased white blood cells)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Sensory disturbance (sense disturbance)
Synovial cyst (cyst of joint filled with synovial fluid)
Urinary tract infection
Fatigue (feeling of tiredness)

50-59:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Rash
Spinal osteoarthritis (joint cartilage loss in spine)
Tenderness (pain or discomfort when an affected area is touched)
Tibia fracture (fracture of lower leg bone)
Abdominal pain upper
Abscess (pus)
Allodynia (a condition in which pain is caused by a stimulus that does not normally elicit pain)
Aortic arteriosclerosis (hardening of the aortic arteries)
Atelectasis (partial or complete collapse of the lung)

60+:

Fatigue (feeling of tiredness)
Migraine (headache)
Pulmonary embolism (blockage of the main artery of the lung)

What are the existing conditions these people have? *

Depression: 17 people, 32.69%
Birth Control: 10 people, 19.23%
Stress And Anxiety: 9 people, 17.31%
Bone Density Abnormal: 6 people, 11.54%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 11.54%
Pain In Extremity: 5 people, 9.62%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 7.69%
Premenstrual Syndrome: 4 people, 7.69%
Osteoporosis (bones weak and more likely to break): 4 people, 7.69%
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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