Adempas and Entresto drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adempas (riociguat) and Entresto (sacubitril; valsartan). Common drug interactions include cough among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Adempas and Entresto. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Adempas?

Adempas has active ingredients of riociguat. eHealthMe is studying from 29,741 Adempas users. Check the latest studies of Adempas.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,628 Entresto users. Check the latest studies of Entresto.



On Jul, 13, 2026

16 people who take Adempas and Entresto together, and have interactions are studied.

Adempas and Entresto drug interactions.

What are the common drug interactions of Adempas and Entresto, by gender? *:

female:

  1. Cough
  2. Decreased appetite
  3. Fatigue (feeling of tiredness)
  4. Nausea (feeling of having an urge to vomit)
  5. Chest pain
  6. Dizziness
  7. Dizziness exertional
  8. Dizziness postural
  9. Dry throat
  10. Dyspepsia (indigestion)

male:

  1. Diarrhoea
  2. Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
  3. Device dislocation
  4. Infusion site pain
  5. Death
  6. Dehydration (dryness resulting from the removal of water)
  7. Oedema (fluid collection in tissue)
  8. Pulmonary oedema (fluid accumulation in the lungs)

What are the common drug interactions of Adempas and Entresto, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Influenza
  2. Nasopharyngitis (inflammation of the nasopharynx)
  3. Chest discomfort
  4. Death
  5. Dyspnoea (difficult or laboured respiration)
  6. Pleural effusion (water on the lungs)
  7. Anaemia (lack of blood)
  8. Cardiac failure congestive
  9. Haematochezia (passage of stools containing blood)
  10. Hyperkalaemia (damage to or disease of the kidney)

What are the existing conditions these people have? *

  1. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 9 people, 56.25%
  2. Hereditary Angioedema (recurrent episodes of severe swelling): 3 people, 18.75%
  3. Oedema Due To Cardiac Disease (fluid collection in tissue due to heart disease): 2 people, 12.50%
  4. Cardiac Failure: 2 people, 12.50%
  5. Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 6.25%
  6. Left Ventricular Failure (left ventricle fails to contract forcefully): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Adempas and Entresto?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Adempas and Entresto:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Adempas:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Entresto:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Adempas and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Entresto and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on riociguat and sacubitril; valsartan (the active ingredients of Adempas and Entresto, respectively), and Adempas and Entresto (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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