Adempas and Zolpidem drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adempas (riociguat) and Zolpidem (zolpidem tartrate). Common drug interactions include choking among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Adempas and Zolpidem. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Adempas?

Adempas has active ingredients of riociguat. eHealthMe is studying from 29,741 Adempas users. Check the latest studies of Adempas.

What is Zolpidem?

Zolpidem has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 92,695 Zolpidem users. Check the latest studies of Zolpidem.

On Jul, 09, 2026

98 people who take Adempas and Zolpidem together, and have interactions are studied.

What are the common drug interactions of Adempas and Zolpidem, by gender? *:

female:

Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Pulmonary arterial pressure decreased
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Malaise (a feeling of general discomfort or uneasiness)
Dehydration (dryness resulting from the removal of water)
Flushing (the warm, red condition of human skin)
Abdominal pain
Cough
Dizziness

male:

Nausea (feeling of having an urge to vomit)
Hypoxia (low oxygen in tissues)
Erythema (redness of the skin)
Pain in extremity
Abdominal distension
Diarrhoea
Blood pressure decreased
Hypotension (abnormally low blood pressure)
Pain
Cardiac disorder

What are the common drug interactions of Adempas and Zolpidem, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal discomfort
Acne (skin problems that cause pimples)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood potassium decreased
Blood pressure decreased
Blood thyroid stimulating hormone decreased
Catheter site erythema (redness of skin at catheter site)
Catheter site haematoma (blood clot at catheter site)
Catheter site haemorrhage (bleeding at catheter site)

30-39:

Alanine aminotransferase increased
Anaemia (lack of blood)
Capillary permeability increased (increased ability of small blood vessels to pass fluid in and out)
Cardiac failure
Device related infection
Epistaxis (bleed from the nose)
Prerenal failure
Pulmonary hypertension (increase in blood pressure in the lung artery)
Renal impairment (severely reduced kidney function)
Sepsis (a severe blood infection that can lead to organ failure and death)

40-49:

Headache (pain in head)
Pyrexia (fever)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Dizziness
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Vomiting

50-59:

Diarrhoea
Flushing (the warm, red condition of human skin)
Drug level decreased
Erythema (redness of the skin)
Headache (pain in head)
Weight increased
Dizziness
Hypoxia (low oxygen in tissues)
Abdominal distension
Chest pain

60+:

Nausea (feeling of having an urge to vomit)
Hypoxia (low oxygen in tissues)
Concomitant disease progression (progress in accompanying disease)
Duodenal neoplasm (tumour of duodenal)
Electrolyte imbalance
Loss of consciousness
Myelofibrosis (a disease in which abnormal blood cells and fibres build up inside the bone marrow)
Pancreatitis (inflammation of pancreas)
Platelet count decreased
Pleural effusion (water on the lungs)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 78 people, 79.59%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 20 people, 20.41%
Right Ventricular Failure (right half of the heart fails to work): 7 people, 7.14%
Pain: 6 people, 6.12%
High Blood Pressure: 6 people, 6.12%
Sleep Disorder: 5 people, 5.10%
Diarrhea: 5 people, 5.10%
Cardiac Failure: 5 people, 5.10%

* Approximation only. Some reports may have incomplete information.

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