Adipex-p and Aldactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adipex-p (phentermine hydrochloride) and Aldactone (spironolactone). Common drug interactions include splenomegaly among females and aortic valve incompetence among males.

The phase IV clinical study analyzes what interactions people have when they take Adipex-p and Aldactone. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Adipex-p?

Adipex-p has active ingredients of phentermine hydrochloride. It is often used in weight loss. eHealthMe is studying from 2,718 Adipex-p users. Check the latest studies of Adipex-p.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

On Jul, 18, 2026

11 people who take Adipex-p and Aldactone together, and have interactions are studied.

Adipex-p and Aldactone drug interactions.

What are the common drug interactions of Adipex-P and Aldactone, by gender? *:

female:

Splenomegaly (enlargement of spleen)
Blood bilirubin increased
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Fatigue (feeling of tiredness)
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Hepatitis (inflammation of the liver)
Lethargy (tiredness)
Aortic valve incompetence
Asthma
Atrial tachycardia (rhythm disturbance that arises in the atria)

male:

Aortic valve incompetence
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Mitral valve incompetence (inefficient heart valve)
Pulmonary hypertension primary (increase in blood pressure in the lung artery with no cause)

What are the common drug interactions of Adipex-P and Aldactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Malaise (a feeling of general discomfort or uneasiness)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Splenomegaly (enlargement of spleen)
Blood bilirubin increased
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Fatigue (feeling of tiredness)

50-59:

n/a

60+:

Chills (felling of cold)
Diarrhoea
Pruritus (severe itching of the skin)
Pruritus generalised (generalized itching)
Tremor (trembling or shaking movements in one or more parts of your body)
Weight increased
Drug hypersensitivity
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)

What are the existing conditions these people have? *

Wheezing (a high-pitched whistling sound made while you breath): 2 people, 18.18%
Type 2 Diabetes: 2 people, 18.18%
Pain: 2 people, 18.18%
Headache (pain in head): 2 people, 18.18%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 18.18%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 2 people, 18.18%
Tension Headache: 1 person, 9.09%
Neuralgia (pain in one or more nerves): 1 person, 9.09%
High Blood Pressure: 1 person, 9.09%
Fever: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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