Advair hfa and Optivar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advair hfa (fluticasone propionate; salmeterol xinafoate) and Optivar (azelastine hydrochloride). Common drug interactions include eczema among females and abscess limb among males.

The phase IV clinical study analyzes what interactions people have when they take Advair hfa and Optivar. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Advair hfa?

Advair hfa has active ingredients of fluticasone propionate; salmeterol xinafoate. It is often used in asthma. eHealthMe is studying from 69,790 Advair hfa users. Check the latest studies of Advair hfa.

What is Optivar?

Optivar has active ingredients of azelastine hydrochloride. eHealthMe is studying from 367 Optivar users. Check the latest studies of Optivar.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

16 people who take Advair hfa and Optivar together, and have interactions are studied.

Advair hfa and Optivar drug interactions.

What are the common drug interactions of Advair Hfa and Optivar, by gender? *:

female:

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Anxiety
Skin irritation
Sunburn
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Arthralgia (joint pain)
Dry skin
Femur fracture
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
Nausea (feeling of having an urge to vomit)

male:

Abscess limb (limb infection)
Cellulitis (infection under the skin)
Tooth abscess (pus formation in tooth)
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
Gangrene (body tissue dies)
Groin abscess (pus in groin)
Leukocytosis (increased white blood cells)
Malignant melanoma (skin cancer rises from melancytes)
Scrotal abscess (pus in scrotum)

What are the common drug interactions of Advair Hfa and Optivar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anaphylactic reaction (serious allergic reaction)
Dry mouth
Dry skin
Dyspepsia (indigestion)
Epistaxis (bleed from the nose)
Eye pruritus (eye itching)
Lip swelling
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nausea (feeling of having an urge to vomit)
Oral candidiasis (fungal infection of mouth)

40-49:

Skin disorder (skin disease)
Abscess limb (limb infection)
Cellulitis (infection under the skin)
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
Gangrene (body tissue dies)
Groin abscess (pus in groin)
Leukocytosis (increased white blood cells)
Scrotal abscess (pus in scrotum)
Testicular abscess (pus in testes)

50-59:

Malignant melanoma (skin cancer rises from melancytes)

60+:

Alopecia (absence of hair from areas of the body)
Dry skin
Ear disorder
Pharyngeal disorder

What are the existing conditions these people have? *

Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 4 people, 25.00%
Constipation: 2 people, 12.50%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 12.50%
Osteoporosis (bones weak and more likely to break): 2 people, 12.50%
Lung Neoplasm Malignant (cancer tumour of lung): 2 people, 12.50%
Weight Decreased: 1 person, 6.25%
Hypotension (abnormally low blood pressure): 1 person, 6.25%
Anaemia (lack of blood): 1 person, 6.25%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 6.25%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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