Advil pm and Ibu drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advil pm (diphenhydramine hydrochloride; ibuprofen) and Ibu (ibuprofen). Common drug interactions include diarrhoea among females and accident among males.

The phase IV clinical study analyzes what interactions people have when they take Advil pm and Ibu. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Advil pm?

Advil pm has active ingredients of diphenhydramine hydrochloride; ibuprofen. It is often used in insomnia. eHealthMe is studying from 1,445 Advil pm users. Check the latest studies of Advil pm.

What is Ibu?

Ibu has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 246,531 Ibu users. Check the latest studies of Ibu.

On Jul, 12, 2026

15 people who take Advil pm and Ibu together, and have interactions are studied.

What are the common drug interactions of Advil Pm and Ibu, by gender? *:

female:

Diarrhoea
Erythema (redness of the skin)
Local swelling (swelling at the site of some application of substance or injury)
Muscle spasms (muscle contraction)
Uterine disorder
Full blood count decreased
Oedema peripheral (superficial swelling)
Rash pruritic (redness with itching)
Rectal haemorrhage (bleeding from anus)
Arthropathy

male:

Accident
Gait disturbance
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Muscle spasms (muscle contraction)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tendon injury
Drug ineffective
Confusional state
Disturbance in attention

What are the common drug interactions of Advil Pm and Ibu, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug screen positive

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Diarrhoea
Erythema (redness of the skin)
Local swelling (swelling at the site of some application of substance or injury)
Muscle spasms (muscle contraction)
Uterine disorder
Arthropathy
Knee arthroplasty
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood cholesterol increased
Cardiac disorder

60+:

Accident
Full blood count decreased
Death
Disturbance in attention
Fatigue (feeling of tiredness)
Urinary tract infection
Gait disturbance
Muscle spasms (muscle contraction)
Oedema peripheral (superficial swelling)
Rash pruritic (redness with itching)

What are the existing conditions these people have? *

Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 13.33%
Sleep Disorder: 1 person, 6.67%
Prostate Cancer Metastatic: 1 person, 6.67%
Pain In Extremity: 1 person, 6.67%
Muscle Spasms (muscle contraction): 1 person, 6.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 6.67%
Injury: 1 person, 6.67%
High Blood Pressure: 1 person, 6.67%
High Blood Cholesterol: 1 person, 6.67%
Headache (pain in head): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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