Advil and Amitiza drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advil (ibuprofen) and Amitiza (lubiprostone). Common drug interactions include cerebrovascular accident among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Advil and Amitiza. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,534 Advil users. Check the latest studies of Advil.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

63 people who take Advil and Amitiza together, and have interactions are studied.

What are the common drug interactions of Advil and Amitiza, by gender? *:

female:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Confusional state
Conversion disorder (neurological symptoms, such as numbness, blindness, paralysis, or fits without a definable organic cause)
Dehydration (dryness resulting from the removal of water)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Fear
Inappropriate affect
Pelvic haematoma (collection of blood outside of a blood vessel in pelvic region)
Pleural effusion (water on the lungs)
Postoperative ileus

male:

Fall
Abnormal faeces (abnormal stool)
Dysgraphia (impaired ability to learn to write)
Dyspnoea (difficult or laboured respiration)
Electrolyte imbalance
Extrasystoles
Grip strength decreased
Hepatitis c
Joint dislocation (a joint position is changed from normal position)
Mobility decreased (ability to move is reduced)

What are the common drug interactions of Advil and Amitiza, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Diarrhoea
Disease progression
Injection site pain
Polymenorrhoea (menstrual disorder)
Urinary tract infection

30-39:

Drug exposure during pregnancy
Pregnancy
Pruritus (severe itching of the skin)
Weight increased
Abdominal distension
Abnormal faeces (abnormal stool)
Alopecia (absence of hair from areas of the body)
Burning sensation
Diarrhoea
Dizziness

40-49:

Anxiety
Urinary tract infection
Fall
Blood pressure increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Eye pain
Hypoaesthesia (reduced sense of touch or sensation)
Impaired driving ability

50-59:

Skin burning sensation
Surgery
Fatigue (feeling of tiredness)
Back pain
Abdominal pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Abdominal pain upper
Adverse event
Anxiety
Dizziness

60+:

Abnormal faeces (abnormal stool)
Fall
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysgraphia (impaired ability to learn to write)
Dyspnoea (difficult or laboured respiration)
Electrolyte imbalance
Extrasystoles
Grip strength decreased
Hepatitis c
Joint dislocation (a joint position is changed from normal position)

What are the existing conditions these people have? *

Stress And Anxiety: 11 people, 17.46%
Depression: 10 people, 15.87%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 15.87%
Headache (pain in head): 9 people, 14.29%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 14.29%
Back Pain: 9 people, 14.29%
Irritable Bowel Syndrome: 9 people, 14.29%
Gastritis (inflammation of stomach): 8 people, 12.70%
Urinary Tract Infection: 7 people, 11.11%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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