Advil and Caffeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advil (ibuprofen) and Caffeine (caffeine). Common drug interactions include back pain among females and cardio-respiratory arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Advil and Caffeine. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,533 Advil users. Check the latest studies of Advil.

What is Caffeine?

Caffeine has active ingredients of caffeine. It is often used in fatigue. eHealthMe is studying from 6,667 Caffeine users. Check the latest studies of Caffeine.

On Jul, 12, 2026

61 people who take Advil and Caffeine together, and have interactions are studied.

What are the common drug interactions of Advil and Caffeine, by gender? *:

female:

Back pain
Blood pressure immeasurable
Dermatitis diaper (diaper rash is a common form of inflamed skin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Weight decreased
Depression
Feeling hot
Hypersensitivity
Alopecia (absence of hair from areas of the body)

male:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Coronary artery stenosis (narrowing of coronary artery)
Influenza
Migraine (headache)
Mycobacterium avium complex infection
Overdose
Pain in jaw
Panic attack
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Terminal state (the transitional states between life and biological death)

What are the common drug interactions of Advil and Caffeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Dry throat
Dyspnoea (difficult or laboured respiration)

30-39:

Anxiety
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Depression
Nonalcoholic fatty liver disease
Hypoaesthesia (reduced sense of touch or sensation)
Panic attack
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Abdominal distension
Dyspnoea (difficult or laboured respiration)

40-49:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hysterectomy
Surgery

50-59:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Coronary artery stenosis (narrowing of coronary artery)
Pulmonary congestion (congestion in the lungs)

60+:

Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Dizziness
Feeding disorder (when children refuse to eat certain food groups)
Feeling hot
Gastrointestinal infection (infection of stomach and intestine)
Hemiparesis (weakness on one side of the body)
Hypersensitivity
Joint stiffness
Mouth ulceration (mouth ulcers)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 21.31%
Headache (pain in head): 8 people, 13.11%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 11.48%
Migraine (headache): 6 people, 9.84%
Gait Disturbance: 5 people, 8.20%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 6.56%

* Approximation only. Some reports may have incomplete information.

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