Advil and Climara drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advil (ibuprofen) and Climara (estradiol). Common drug interactions include breast cancer among females.

The phase IV clinical study analyzes what interactions people have when they take Advil and Climara. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,533 Advil users. Check the latest studies of Advil.

What is Climara?

Climara has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,706 Climara users. Check the latest studies of Climara.

On Jul, 13, 2026

27 people who take Advil and Climara together, and have interactions are studied.

What are the common drug interactions of Advil and Climara, by gender? *:

female:

Breast cancer
Hot flush (sudden feelings of heat)
Blood pressure increased
Bone pain
Hyperphagia (an abnormal appetite for food)
Insomnia (sleeplessness)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Pathological gambling
Anxiety
Breast mass

male:

n/a

What are the common drug interactions of Advil and Climara, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Application site reaction

40-49:

Application site reaction
Vulvovaginal dryness

50-59:

Platelet count decreased
Pleural effusion (water on the lungs)
Pneumonia
Pyrexia (fever)
Restless legs syndrome (a powerful urge to move your legs)
Sinusitis (inflammation of sinus)
Temperature intolerance (inability to go in temperature)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Thrombocytosis
Tremor (trembling or shaking movements in one or more parts of your body)

60+:

Hot flush (sudden feelings of heat)
Abdominal pain
Fatigue (feeling of tiredness)
Gait disturbance
Hypertension (high blood pressure)
Insomnia (sleeplessness)
Irritability
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Pain in extremity

What are the existing conditions these people have? *

Stress And Anxiety: 7 people, 25.93%
Depression: 5 people, 18.52%
Migraine (headache): 4 people, 14.81%
Multiple Myeloma (cancer of the plasma cells): 4 people, 14.81%
High Blood Pressure: 4 people, 14.81%
Joint Pain: 4 people, 14.81%
Menopausal Symptoms: 4 people, 14.81%
Acarodermatitis (skin inflammation caused by mites (acarids)): 4 people, 14.81%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 14.81%
Osteopenia (a condition where bone mineral density is lower than normal): 4 people, 14.81%

* Approximation only. Some reports may have incomplete information.

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