Advil and Fentanyl citrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advil (ibuprofen) and Fentanyl citrate (fentanyl citrate). Common drug interactions include spinal osteoarthritis among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Advil and Fentanyl citrate. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,533 Advil users. Check the latest studies of Advil.

What is Fentanyl citrate?

Fentanyl citrate has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 21,294 Fentanyl citrate users. Check the latest studies of Fentanyl citrate.

On Jul, 08, 2026

39 people who take Advil and Fentanyl citrate together, and have interactions are studied.

Advil and Fentanyl citrate drug interactions.

What are the common drug interactions of Advil and Fentanyl Citrate, by gender? *:

female:

Spinal osteoarthritis (joint cartilage loss in spine)
Toothache (tooth pain)
Weight decreased
Tooth extraction
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Dyspnoea (difficult or laboured respiration)
Nerve block (the interruption of signals travelling along a nerve)
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Arteriosclerosis (thickening and hardening of arteries)
Colonic stenosis (abnormal narrowing of colon)

male:

Nausea (feeling of having an urge to vomit)
Anaemia (lack of blood)
Bone disorder
Metastasis (spreadable cancer to other organ from origin)
Mouth ulceration (mouth ulcers)
Oral pain
Osteonecrosis (death of bone)
Prostate cancer metastatic
Aortic valve incompetence
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)

What are the common drug interactions of Advil and Fentanyl Citrate, by age (0-1 to 60+)? *:

0-1:

Prothrombin level decreased
Transaminases increased

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Apnoea (suspension of external breathing)
Aura
Cholecystitis acute (rapid infection of gallbladder)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Depressed level of consciousness
Diabetes mellitus inadequate control
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Foot fracture
Gallbladder disorder
Hyperbilirubinaemia (excess of bilirubin in the blood)

40-49:

Anxiety
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone disorder
Impaired healing
Injury
Metastases to bone (cancer spreads to bone)
Gastritis (inflammation of stomach)
Nausea (feeling of having an urge to vomit)
Neck pain

50-59:

Fatigue (feeling of tiredness)
Femur fracture
Flatulence (flatus expelled through the anus)
Foot deformity (functional disability of foot)
Foot fracture
Fracture nonunion (permanent failure of healing following a broken bone)
Fungal infection
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Gynaecomastia (enlargement of the gland tissue of the male breast)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)

60+:

Anaemia (lack of blood)
Asthenia (weakness)
Bone disorder
Metastasis (spreadable cancer to other organ from origin)
Mouth ulceration (mouth ulcers)
Oral pain
Osteonecrosis (death of bone)
Prostate cancer metastatic
Aortic valve incompetence
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 12 people, 30.77%
Prostate Cancer Metastatic: 3 people, 7.69%
Constipation: 3 people, 7.69%
Breast Cancer: 3 people, 7.69%
Muscle Spasms (muscle contraction): 2 people, 5.13%
Breast Cancer Metastatic: 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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