Advil and Midazolam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advil (ibuprofen) and Midazolam (midazolam). Common drug interactions include nephrogenic anaemia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Advil and Midazolam. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,533 Advil users. Check the latest studies of Advil.

What is Midazolam?

Midazolam has active ingredients of midazolam. eHealthMe is studying from 11,246 Midazolam users. Check the latest studies of Midazolam.

On Jul, 16, 2026

15 people who take Advil and Midazolam together, and have interactions are studied.

What are the common drug interactions of Advil and Midazolam, by gender? *:

female:

Nephrogenic anaemia (anaemia due to kidney disease)
Anal abscess
Cellulitis (infection under the skin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Vulval abscess
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Bone density decreased

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Nephrogenic anaemia (anaemia due to kidney disease)
Back pain
Gait disturbance
Hospitalisation
Overdose

What are the common drug interactions of Advil and Midazolam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hospitalisation
Overdose

40-49:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Death
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypotension (abnormally low blood pressure)
Renal cell carcinoma stage i (the tumour is 7 centimetres or smaller and is found only in the kidney)
Renal hypertension (high blood pressure caused by the kidneys hormonal response)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Emotional distress
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Fatigue (feeling of tiredness)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis postmenopausal (weak bone with possibility to break after stopped menstrual cycles)
Renal tubular necrosis (death of kidney tubules)

60+:

Urinary tract infection
Anal abscess
Cellulitis (infection under the skin)
Colorectal cancer stage iii (colon and rectal cancer spreads to lymph nodes)
Sepsis (a severe blood infection that can lead to organ failure and death)
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Vulval abscess

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 53.33%
High Blood Cholesterol: 5 people, 33.33%
High Blood Pressure: 3 people, 20.00%
Diabetes: 3 people, 20.00%
Stress And Anxiety: 3 people, 20.00%
Hiv Infection: 2 people, 13.33%
Oedema (fluid collection in tissue): 2 people, 13.33%
Blood Pressure Abnormal: 2 people, 13.33%
Nausea (feeling of having an urge to vomit): 2 people, 13.33%
Neuralgia (pain in one or more nerves): 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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