Advil and Msm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advil (ibuprofen) and Msm (methylsulfonylmethane). Common drug interactions include dysphonia among females and arthropathy among males.

The phase IV clinical study analyzes what interactions people have when they take Advil and Msm. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,533 Advil users. Check the latest studies of Advil.

What is Msm?

Msm has active ingredients of methylsulfonylmethane. It is often used in joint pain. eHealthMe is studying from 1,210 Msm users. Check the latest studies of Msm.

On Jul, 18, 2026

18 people who take Advil and Msm together, and have interactions are studied.

What are the common drug interactions of Advil and Msm, by gender? *:

female:

Dysphonia (speech disorder attributable to a disorder of phonation)
Eye pain
Nausea (feeling of having an urge to vomit)
Photophobia (extreme sensitivity to light)
Pruritus (severe itching of the skin)
Serum ferritin increased
Skin lesion
Tooth fracture
Vision blurred
Abnormal loss of weight

male:

Arthropathy
Fall
Balance disorder
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bladder outlet obstruction (urological condition where the urine flow from the urinary bladder through the urethra is impeded)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Bone cyst
Bone disorder
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)

What are the common drug interactions of Advil and Msm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Depression
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Diabetic microangiopathy (small blood vessels of the body are damaged due to diabetes)
Diarrhoea
Discomfort
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Dizziness
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Essential hypertension (primary hypertension)

20-29:

n/a

30-39:

Blindness
Eye pain
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Photophobia (extreme sensitivity to light)
Vision blurred
Toxic optic neuropathy (optic nerve damage caused by toxic (harmful) substances)

40-49:

n/a

50-59:

Drug hypersensitivity
Drug ineffective
Dysphonia (speech disorder attributable to a disorder of phonation)
Oropharyngeal pain
Confusional state
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Irritability
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Onychomadesis (a periodic idiopathic shedding of the nails)

60+:

Drug ineffective
Asthenia (weakness)
Abnormal loss of weight
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bone pain
Cardiac disorder
Cardiac murmur (an heart sound in valve abnormality)
Contusion (a type of hematoma of tissue in which capillaries)
Deafness unilateral
Diarrhoea

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 22.22%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 3 people, 16.67%
Hypersensitivity: 3 people, 16.67%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 11.11%
Joint Stiffness: 2 people, 11.11%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 11.11%
Multiple Myeloma (cancer of the plasma cells): 2 people, 11.11%
High Blood Pressure: 2 people, 11.11%
Arthropathy: 2 people, 11.11%
Breast Cancer Stage Iv: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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