Advil and Periactin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advil (ibuprofen) and Periactin (cyproheptadine hydrochloride). Common drug interactions include depression among females and activities of daily living impaired among males.

The phase IV clinical study analyzes what interactions people have when they take Advil and Periactin. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,534 Advil users. Check the latest studies of Advil.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

13 people who take Advil and Periactin together, and have interactions are studied.

What are the common drug interactions of Advil and Periactin, by gender? *:

female:

Depression
Pathological gambling
Compulsive shopping
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Suicidal ideation
Acute myocardial infarction (acute heart attack)
Anaemia of chronic disease
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)

male:

Activities of daily living impaired
Asthma
Dysarthria (speech disorder)
Dystonia (abnormal muscle tone)
Fatigue (feeling of tiredness)
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back))
Lethargy (tiredness)
Pain in extremity
Pancreatitis (inflammation of pancreas)
Salivary hypersecretion (excess saliva secretion)

What are the common drug interactions of Advil and Periactin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Activities of daily living impaired
Asthma
Bone pain
Chest discomfort
Chest pain
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Constipation
Discomfort
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysarthria (speech disorder)

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Depression
Drug hypersensitivity
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Impaired work ability
Laryngitis (inflammation of the larynx)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

50-59:

Ascites (accumulation of fluid in the abdominal cavity)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Muscle spasms (muscle contraction)

60+:

Acute myocardial infarction (acute heart attack)
Anaemia of chronic disease
Hip fracture
Hypertension (high blood pressure)
Lung neoplasm (tumour of lung)
Urinary tract infection
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Blood potassium decreased
Depression
Fall

What are the existing conditions these people have? *

High Blood Pressure: 7 people, 53.85%
Itching: 5 people, 38.46%
Joint Pain: 4 people, 30.77%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 30.77%
Weakness: 4 people, 30.77%
Laryngitis (inflammation of the larynx): 4 people, 30.77%
Depression: 4 people, 30.77%
Insomnia (sleeplessness): 3 people, 23.08%
Seasonal Allergy (allergic condition due to certain season): 2 people, 15.38%
Arthropathy: 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Advil and Periactin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously