Advil and Pioglitazone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advil (ibuprofen) and Pioglitazone (pioglitazone hydrochloride). Common drug interactions include joint swelling among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Advil and Pioglitazone. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,533 Advil users. Check the latest studies of Advil.

What is Pioglitazone?

Pioglitazone has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 12,864 Pioglitazone users. Check the latest studies of Pioglitazone.

On Jul, 27, 2026

35 people who take Advil and Pioglitazone together, and have interactions are studied.

Advil and Pioglitazone drug interactions.

What are the common drug interactions of Advil and Pioglitazone, by gender? *:

female:

Joint swelling
Limb injury
Oral herpes (viral infection of mouth)
Oropharyngeal pain
Osteoporosis (bones weak and more likely to break)
Oxygen saturation decreased
Pyrexia (fever)
Rectal prolapse (falling of rectum from normal place)
Sinusitis (inflammation of sinus)
Stress

male:

Fall
Renal failure (kidney dysfunction)
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anal abscess
Back pain
Cardiac failure congestive
Cerebral haemorrhage (bleeding within the brain)
Chronic kidney disease
Concussion (short loss of normal brain function in response to a head injury)

What are the common drug interactions of Advil and Pioglitazone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Cardiac failure congestive
Chest pain
Chronic kidney disease
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diabetic nephropathy (diabetic kidney disease)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hyperhidrosis (abnormally increased sweating)
Hypertensive heart disease
Nephropathy (damage to or disease of a kidney)

40-49:

Chronic kidney disease
Dyspepsia (indigestion)
Erythema (redness of the skin)
Hot flush (sudden feelings of heat)
Nausea (feeling of having an urge to vomit)
Post-traumatic stress disorder
Renal failure (kidney dysfunction)
Vomiting
Anxiety disorder
Borderline personality disorder

50-59:

Pruritus (severe itching of the skin)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Pneumonia
Dizziness
Neuropathy peripheral (surface nerve damage)
Blood pressure increased
Fatigue (feeling of tiredness)
Hypersensitivity
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)

60+:

Fall
Drug ineffective
Cerebral haemorrhage (bleeding within the brain)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Concussion (short loss of normal brain function in response to a head injury)
Drug hypersensitivity
Genital abscess (build up of pus in genital)
Head injury
Localised infection (infection at the single location)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 7 people, 20.00%
High Blood Pressure: 5 people, 14.29%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 8.57%
High Blood Cholesterol: 3 people, 8.57%
Headache (pain in head): 3 people, 8.57%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.57%
Type 2 Diabetes: 2 people, 5.71%
Parkinson's Disease: 2 people, 5.71%
Lung Cancer - Non-Small Cell (lung cancer): 2 people, 5.71%
Joint Pain: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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