Advil and Plendil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advil (ibuprofen) and Plendil (felodipine). Common drug interactions include carpal tunnel syndrome among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Advil and Plendil. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,534 Advil users. Check the latest studies of Advil.

What is Plendil?

Plendil has active ingredients of felodipine. It is often used in high blood pressure. eHealthMe is studying from 4,990 Plendil users. Check the latest studies of Plendil.

On Aug, 06, 2026

19 people who take Advil and Plendil together, and have interactions are studied.

What are the common drug interactions of Advil and Plendil, by gender? *:

female:

Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Dysphagia (a condition in which swallowing is difficult or painful)
Fall
Fear
Infection
Intervertebral disc degeneration (spinal disc degeneration)
Limb injury
Nephrosclerosis (hardening of the kidney due to renovascular disease)
Osteonecrosis (death of bone)
Pleuritic pain

male:

Death
Dysstasia (difficulty in standing)
Confusional state
Constipation
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dry skin
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Humerus fracture (injury to the upper arm bone)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)

What are the common drug interactions of Advil and Plendil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Vasovagal attack (malaise mediated by the vagus nerve)

50-59:

Arteriosclerosis (thickening and hardening of arteries)
Blood creatine phosphokinase increased
Blood glucose increased
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Cardiomegaly (increased size of heart than normal)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Needle track marks
Overdose
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Pulmonary congestion (congestion in the lungs)

60+:

Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Dysphagia (a condition in which swallowing is difficult or painful)
Pyrexia (fever)
Renal artery stenosis (narrowing of renal artery)
Renal cyst (kidney cyst)
Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below)
Tooth abscess (pus formation in tooth)
Vascular pseudoaneurysm (leakage of arterial blood from an artery into the surrounding tissue with a continuing communication between the originating artery and the resultant adjacent cavity)
Vomiting
Weight increased

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 8 people, 42.11%
Renal Disorder (kidney disease): 4 people, 21.05%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 3 people, 15.79%
Iron Overload: 2 people, 10.53%
Sedation: 1 person, 5.26%
Renal Cell Carcinoma (a kidney cancer): 1 person, 5.26%
Osteoporosis (bones weak and more likely to break): 1 person, 5.26%
Malignant Urinary Tract Neoplasm (cancer tumour of urinary tract organs): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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