Advil and Sumatriptan succinate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advil (ibuprofen) and Sumatriptan succinate (sumatriptan succinate). Common drug interactions include disturbance in attention among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Advil and Sumatriptan succinate. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,534 Advil users. Check the latest studies of Advil.

What is Sumatriptan succinate?

Sumatriptan succinate has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 9,731 Sumatriptan succinate users. Check the latest studies of Sumatriptan succinate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

82 people who take Advil and Sumatriptan succinate together, and have interactions are studied.

Advil and Sumatriptan succinate drug interactions.

What are the common drug interactions of Advil and Sumatriptan Succinate, by gender? *:

female:

Disturbance in attention
Dyspepsia (indigestion)
Impaired work ability
Memory impairment
Panic attack
Parosmia (distortion of the sense of smell, as in smelling odours that are not present)
Anxiety
Fatigue (feeling of tiredness)
Drug ineffective
Emotional distress

male:

Drug ineffective
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Infection
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Productive cough
Pyrexia (fever)
White blood cell count decreased

What are the common drug interactions of Advil and Sumatriptan Succinate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Fatigue (feeling of tiredness)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)

10-19:

Abdominal discomfort
Abdominal pain upper
Back pain
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Gallbladder injury
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Productive cough
Vomiting

20-29:

Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis (infection of gallbladder)
Decreased appetite
Dyspepsia (indigestion)
Injury
Weight decreased
Abdominal distension
Anxiety
Brain stem infarction (brainstem stroke)

30-39:

Emotional distress
Injury
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
General physical health deterioration (weak health status)
Pulmonary embolism (blockage of the main artery of the lung)
Abdominal pain
Cellulitis (infection under the skin)
Cystitis (inflammation of the wall of the bladder)
Fall

40-49:

Bone density decreased
Drug ineffective
Abdominal discomfort
Adverse event
Alopecia (absence of hair from areas of the body)
Drug intolerance (drug sensitivity)
Dyspnoea (difficult or laboured respiration)
Fear
Feeling of despair
Frustration (a form of poorly expressed anger)

50-59:

Idiopathic thrombocytopenic purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting)
Oedema peripheral (superficial swelling)
Palpitations (feelings or sensations that your heart is pounding or racing)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Thrombocytopenia (decrease of platelets in blood)
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Postmenopausal haemorrhage (post-menopausal bleeding)
Pyrexia (fever)
Tongue coated

60+:

Dizziness
Abdominal discomfort
Abdominal pain upper
Anxiety
Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Cataract (clouding of the lens inside the eye)
Constipation
Cough

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 15.85%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 13.41%
Immunodeficiency Common Variable: 6 people, 7.32%
Headache (pain in head): 6 people, 7.32%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 5 people, 6.10%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 6.10%

* Approximation only. Some reports may have incomplete information.

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