Advil and Versed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advil (ibuprofen) and Versed (midazolam hydrochloride). Common drug interactions include renal impairment among females and injury among males.

The phase IV clinical study analyzes what interactions people have when they take Advil and Versed. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,533 Advil users. Check the latest studies of Advil.

What is Versed?

Versed has active ingredients of midazolam hydrochloride. It is often used in sedation during medical procedure. eHealthMe is studying from 6,869 Versed users. Check the latest studies of Versed.

On Jul, 12, 2026

61 people who take Advil and Versed together, and have interactions are studied.

What are the common drug interactions of Advil and Versed, by gender? *:

female:

Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Stress
Urinary tract infection
Abdominal pain upper
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Agitation (state of anxiety or nervous excitement)
Anaemia (lack of blood)
Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Ascites (accumulation of fluid in the abdominal cavity)

male:

Injury
Cellulitis (infection under the skin)
Anaemia (lack of blood)
Blood urine present
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Fear
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematochezia (passage of stools containing blood)
Hypertension (high blood pressure)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

What are the common drug interactions of Advil and Versed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Duodenal ulcer
Duodenitis (inflammation of the duodenum)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Urinary tract infection
Febrile convulsion (a convulsion associated with a significant rise in body temperature)
Lower respiratory tract infection viral
Mucosal discolouration (change in colour of mucosal membrane)
Parainfluenzae virus infection
Pyrexia (fever)
Respiratory distress (difficulty in breathing)

20-29:

Altered state of consciousness (altered state of mind)
Anxiety
Atypical pneumonia (acute respiratory disease marked by high fever and coughing)
Botulism (food poisoning caused by botulinum growing)
Breath sounds
Cellulitis (infection under the skin)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Dysphagia (a condition in which swallowing is difficult or painful)
Eye movement disorder

30-39:

Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Anoxia (low oxygen)
Anxiety
Apnoea (suspension of external breathing)
Aura
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cholecystitis chronic (long lasting infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depressed level of consciousness
Depression

40-49:

Abdominal pain
Fatigue (feeling of tiredness)
Abdominal distension
Device dislocation
Dysmenorrhoea (painful menstruation)
Lymphocyte count decreased
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Migraine (headache)
Uterine haemorrhage (uterine bleeding)
Injury

50-59:

Fibula fracture
Haematocrit decreased
Haemoglobin decreased
Hearing impaired
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic failure (liver failure)
Hepatic neoplasm malignant (liver cancer)
Hypoaesthesia (reduced sense of touch or sensation)
Infection

60+:

Injury
Death
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Renal failure acute (rapid kidney dysfunction)
Stress
Abdominal pain upper
Agitation (state of anxiety or nervous excitement)
Ascites (accumulation of fluid in the abdominal cavity)
Bacterial sepsis

What are the existing conditions these people have? *

Depression: 8 people, 13.11%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 9.84%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 9.84%
High Blood Pressure: 5 people, 8.20%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 8.20%
Constipation: 5 people, 8.20%
Urinary Tract Infection: 4 people, 6.56%
Stress And Anxiety: 4 people, 6.56%
Rashes (redness): 4 people, 6.56%
Joint Pain: 4 people, 6.56%

* Approximation only. Some reports may have incomplete information.

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