Ajovy and Tysabri drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ajovy (fremanezumab-vfrm) and Tysabri (natalizumab). Common drug interactions include blood homocysteine increased among females.

The phase IV clinical study analyzes what interactions people have when they take Ajovy and Tysabri. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Ajovy?

Ajovy has active ingredients of fremanezumab-vfrm. eHealthMe is studying from 8,834 Ajovy users. Check the latest studies of Ajovy.

What is Tysabri?

Tysabri has active ingredients of natalizumab. It is often used in multiple sclerosis. eHealthMe is studying from 221,369 Tysabri users. Check the latest studies of Tysabri.

On Aug, 09, 2026

14 people who take Ajovy and Tysabri together, and have interactions are studied.

What are the common drug interactions of Ajovy and Tysabri, by gender? *:

female:

Blood homocysteine increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hypersomnia (excessive daytime sleepiness (eds))
Injection site extravasation (flow of (blood or lymph) from injection site)
Injection site pain
Lung disorder (lung disease)
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Migraine (headache)
Nausea (feeling of having an urge to vomit)

male:

n/a

What are the common drug interactions of Ajovy and Tysabri, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood homocysteine increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Vitamin b12 decreased

40-49:

n/a

50-59:

Nausea (feeling of having an urge to vomit)
Neurological symptom (symptoms of nervous system disease)
Aphasia (damage to the parts of the brain that control language)
Crying
Fall
Femur fracture
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment

60+:

Aortic valve disease
Post procedural complication
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Thrombosis (formation of a blood clot inside a blood vessel)

What are the existing conditions these people have? *

Migraine (headache): 4 people, 28.57%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 14.29%
Pain: 2 people, 14.29%
Tension Headache: 1 person, 7.14%
Insomnia (sleeplessness): 1 person, 7.14%
Headache (pain in head): 1 person, 7.14%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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