Aldactazide and Zocor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactazide (hydrochlorothiazide; spironolactone) and Zocor (simvastatin). Common drug interactions include mitral valve incompetence among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Aldactazide and Zocor. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactazide?

Aldactazide has active ingredients of hydrochlorothiazide; spironolactone. It is often used in high blood pressure. eHealthMe is studying from 1,597 Aldactazide users. Check the latest studies of Aldactazide.

What is Zocor?

Zocor has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 86,545 Zocor users. Check the latest studies of Zocor.

On Jul, 31, 2026

67 people who take Aldactazide and Zocor together, and have interactions are studied.

Aldactazide and Zocor drug interactions.

What are the common drug interactions of Aldactazide and Zocor, by gender? *:

female:

Mitral valve incompetence (inefficient heart valve)
Ovarian cyst (fluid filled sac of the ovary)
Pain in extremity
Renal failure (kidney dysfunction)
Alanine aminotransferase increased
Angina pectoris (chest pain due to ischemia of the heart muscle)
Blood carbon dioxide decreased
Cardiomyopathy (weakening of the heart muscle)
Colon cancer
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Hyperkalaemia (damage to or disease of the kidney)
Angiopathy (generic term for a disease of the blood vessels)
Blood glucose increased
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dehydration (dryness resulting from the removal of water)
Ear infection
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Gout (uric acid crystals building up in the body)

What are the common drug interactions of Aldactazide and Zocor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Muscle cramp (painful sensation caused by muscle contraction)

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Glycosylated haemoglobin increased
Nephrolithiasis (calculi in the kidneys)

50-59:

Sudden death
Blood creatinine increased
Blood urea increased
Cardiovascular disorder (heart diseases)
Cellulitis (infection under the skin)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Circulatory collapse
Cushing's syndrome (obesity, a rounded face, increased fat)
Dehydration (dryness resulting from the removal of water)
Depression

60+:

Chronic kidney disease
Renal injury (kidney injury)
Blood glucose increased
Blood urea increased
Gastric ulcer (stomach ulcer)
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Gout (uric acid crystals building up in the body)
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)

What are the existing conditions these people have? *

Pain: 8 people, 11.94%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 10.45%
Gout (uric acid crystals building up in the body): 6 people, 8.96%
Hyperlipidaemia (presence of excess lipids in the blood): 6 people, 8.96%
Gastric Ulcer (stomach ulcer): 6 people, 8.96%
Renal Disorder (kidney disease): 6 people, 8.96%
Anaemia (lack of blood): 6 people, 8.96%
Cardiac Disorder: 5 people, 7.46%
Stress And Anxiety: 5 people, 7.46%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 5.97%

* Approximation only. Some reports may have incomplete information.

Do you take Aldactazide and Zocor?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously