Aldactone and Augmentin '125' drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactone (spironolactone) and Augmentin '125' (amoxicillin; clavulanate potassium). Common drug interactions include cardiac failure congestive among females and pruritus among males.

The phase IV clinical study analyzes what interactions people have when they take Aldactone and Augmentin '125'. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

What is Augmentin '125'?

Augmentin '125' has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 10,452 Augmentin '125' users. Check the latest studies of Augmentin '125'.

On Jul, 03, 2026

92 people who take Aldactone and Augmentin '125' together, and have interactions are studied.

Aldactone and Augmentin '125' drug interactions.

What are the common drug interactions of Aldactone and Augmentin '125', by gender? *:

female:

Cardiac failure congestive
Pyrexia (fever)
Thrombocytopenia (decrease of platelets in blood)
Urinary tract infection
Aspartate aminotransferase increased
Asthenia (weakness)
Bacteraemia (presence of bacteria in the blood)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dehydration (dryness resulting from the removal of water)

male:

Pruritus (severe itching of the skin)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Cholestatic liver injury (due to injury bile cannot floe from liver)
Fatigue (feeling of tiredness)
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Liver disorder (liver diseases)
Thrombocytopenia (decrease of platelets in blood)
Transaminases increased

What are the common drug interactions of Aldactone and Augmentin '125', by age (0-1 to 60+)? *:

0-1:

Angioedema (rapid swelling of the dermis)
Lip swelling
Local swelling (swelling at the site of some application of substance or injury)
Swelling face

2-9:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Brain injury
Death
Emotional distress
Fear
Injury
Multi-organ failure (multisystem organ failure)
Pain
Renal failure (kidney dysfunction)

10-19:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Cardiac failure
Hyperbilirubinaemia (excess of bilirubin in the blood)
Lung disorder (lung disease)
Respiratory tract infection
Bilirubin conjugated increased
Pneumonia

20-29:

Cardiac disorder
Migraine (headache)
Type 1 diabetes mellitus
Cardiac failure congestive
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Joint injury
Thrombosis (formation of a blood clot inside a blood vessel)
Viral cardiomyopathy (weakness in the muscle of the heart due to viral infection)

30-39:

Bacteraemia (presence of bacteria in the blood)
Suicidal ideation
Urinary tract infection
Alcohol abuse
Drug abuse
Pruritus (severe itching of the skin)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Thrombocytopenia (decrease of platelets in blood)

40-49:

Hepatic failure (liver failure)

50-59:

Dehydration (dryness resulting from the removal of water)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Staphylococcal infection (an infection with staphylococcus bacteria)
Abdominal rigidity
Alanine aminotransferase increased
Angiomyolipoma (most common benign tumour of the kidney)
Anxiety
Aspartate aminotransferase increased
Asthenia (weakness)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)

60+:

Pruritus (severe itching of the skin)
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Blood creatinine increased
Cholangiolitis (inflammation of the bile capillaries)
Fall
Rash
Transaminases increased
Oedema peripheral (superficial swelling)
Blood alkaline phosphatase increased

What are the existing conditions these people have? *

High Blood Pressure: 8 people, 8.70%
Oedema (fluid collection in tissue): 5 people, 5.43%
Hiv Infection: 5 people, 5.43%

* Approximation only. Some reports may have incomplete information.

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