Aldactone and Bextra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactone (spironolactone) and Bextra (valdecoxib). Common drug interactions include angina pectoris among females and acute myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Aldactone and Bextra. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

What is Bextra?

Bextra has active ingredients of valdecoxib. It is often used in pain. eHealthMe is studying from 20,994 Bextra users. Check the latest studies of Bextra.

On Jul, 16, 2026

58 people who take Aldactone and Bextra together, and have interactions are studied.

What are the common drug interactions of Aldactone and Bextra, by gender? *:

female:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Back pain
Blood cholesterol increased
Blood creatinine decreased
Breast cancer
Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Coronary artery stenosis (narrowing of coronary artery)

male:

Acute myocardial infarction (acute heart attack)
Cardiogenic shock (inadequate circulation of blood)
Tooth extraction
Abdominal distension
Gastric ulcer (stomach ulcer)
Gastritis (inflammation of stomach)
Hepatitis (inflammation of the liver)
Jaw disorder (jaw disease)
Paralysis
Renal disorder (kidney disease)

What are the common drug interactions of Aldactone and Bextra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Cough
Insomnia (sleeplessness)
Somnolence (a state of near-sleep, a strong desire for sleep)

30-39:

Blood potassium increased
Cardiac failure
Decreased appetite
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypophagia (reduced food intake)
Hypotension (abnormally low blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Urine output decreased

40-49:

Insomnia (sleeplessness)
Back pain
Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Dyspnoea (difficult or laboured respiration)
Fall
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Muscular weakness (muscle weakness)
Vomiting
Angina pectoris (chest pain due to ischemia of the heart muscle)

50-59:

Rash papular (redness with papule)
Abdominal pain
Burning sensation
Chest pain
Dermatitis allergic (inflammation of the skin due allergic reaction)
Obesity (having too much body fat)
Skin plaque (red, scaly patches to appear on the skin)
Swelling face
Blood cholesterol increased
Breast cancer

60+:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hip fracture
General physical health deterioration (weak health status)
Post procedural infection
Renal failure acute (rapid kidney dysfunction)
Vomiting
Acute myocardial infarction (acute heart attack)
Asthenia (weakness)
Blood pressure decreased
Cardiogenic shock (inadequate circulation of blood)

What are the existing conditions these people have? *

Depression: 19 people, 32.76%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 8.62%
Stress And Anxiety: 4 people, 6.90%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 6.90%
High Blood Pressure: 3 people, 5.17%
Hair Growth Abnormal: 3 people, 5.17%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 3 people, 5.17%
Bipolar Disorder (mood disorder): 3 people, 5.17%
Back Pain: 3 people, 5.17%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 5.17%

* Approximation only. Some reports may have incomplete information.

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