Aldactone and Cortril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactone (spironolactone) and Cortril (hydrocortisone). Common drug interactions include appendicitis among females and pneumothorax among males.

The phase IV clinical study analyzes what interactions people have when they take Aldactone and Cortril. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

What is Cortril?

Cortril has active ingredients of hydrocortisone. eHealthMe is studying from 1,715 Cortril users. Check the latest studies of Cortril.

On Jul, 14, 2026

37 people who take Aldactone and Cortril together, and have interactions are studied.

Aldactone and Cortril drug interactions.

What are the common drug interactions of Aldactone and Cortril, by gender? *:

female:

Appendicitis (inflammation of the appendix)
Arthralgia (joint pain)
Pain in extremity
Rash
Right ventricular failure (right half of the heart fails to work)
Platelet count decreased
Cardiac failure
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic failure (liver failure)
Anaemia (lack of blood)

male:

Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Cardiac failure chronic
Drug ineffective
Psoriasis (immune-mediated disease that affects the skin)
Asthenia (weakness)
Acute respiratory failure
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Ascites (accumulation of fluid in the abdominal cavity)
Candida pneumonia (infection of lung by candida)

What are the common drug interactions of Aldactone and Cortril, by age (0-1 to 60+)? *:

0-1:

Hypotension (abnormally low blood pressure)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Cerebellar haemorrhage (bleeding in cerebeller)

2-9:

Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Death
Cytomegalovirus infection
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Hepatitis (inflammation of the liver)

10-19:

n/a

20-29:

n/a

30-39:

Dermatitis allergic (inflammation of the skin due allergic reaction)
Device related infection
Diarrhoea
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Helicobacter gastritis (inflammation of the inner lining of the stomach caused by helicobacter pylori (h. pylori) a bacterium)
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults)
Influenza
Injection site eczema (injection site -patches of skin become rough and inflamed, with itching and bleeding blisters)
Injection site erosion
Injection site erythema (redness at injection site)

40-49:

n/a

50-59:

Appendicitis (inflammation of the appendix)
Arthralgia (joint pain)
Pain in extremity
Rash
Right ventricular failure (right half of the heart fails to work)
Cardiac failure
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic failure (liver failure)
Oedema peripheral (superficial swelling)
Renal impairment (severely reduced kidney function)

60+:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Adrenal disorder
Drug ineffective
Haemolytic uraemic syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more)
Headache (pain in head)
Neoplasm progression (growth of tumour)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss)
Psoriasis (immune-mediated disease that affects the skin)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 14 people, 37.84%
Insomnia (sleeplessness): 8 people, 21.62%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 6 people, 16.22%
Asthma: 5 people, 13.51%
Back Pain: 5 people, 13.51%
Cardiac Failure: 5 people, 13.51%
Constipation: 4 people, 10.81%
Heart Attack: 4 people, 10.81%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 4 people, 10.81%
Hepatitis C: 4 people, 10.81%

* Approximation only. Some reports may have incomplete information.

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